iPTMnet Report for O43184 (ADAM12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43184 / ADA12_HUMAN
Protein Name Disintegrin and metalloproteinase domain-containing protein 12 precursor
Gene Name Name: ADAM12
Synonyms:MLTN;ORFNames:UNQ346/PRO545;
Organism Homo sapiens (Human)

PRO ID PR:O43184
DAG View
PRO Name disintegrin and metalloproteinase domain-containing protein 12 (human)
Definition A disintegrin and metalloproteinase domain-containing protein 12 that is encoded in the genome of human.
Short Label hADAM12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43184 (ADAM12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N111 N-Glycosylation GlyGen 23090970, 24190977
R430 Methylation PhosphoSitePlus
R449 Methylation PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus
Y783 Phosphorylation PhosphoSitePlus
T882 Phosphorylation PhosphoSitePlus
Y895 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R449 S449 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R449 C449 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R449 H449 Biomuta DOID:4362 / cervical cancer [ cosmic ]
T882 I882 Biomuta DOID:9256 / colorectal cancer [ cosmic ]