iPTMnet Report for O43166 (SIPA1L1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43166 / SI1L1_HUMAN
Protein Name Signal-induced proliferation-associated 1-like protein 1
Gene Name Name: SIPA1L1
Synonyms:E6TP1,KIAA0440;
Organism Homo sapiens (Human)

PRO ID PR:O43166
DAG View
PRO Name signal-induced proliferation-associated 1-like protein 1 (human)
Definition A signal-induced proliferation-associated 1-like protein 1 that is encoded in the genome of human.
Short Label hSIPA1L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43166 (SIPA1L1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Methylation PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus
T26 Phosphorylation PhosphoSitePlus
T31 Phosphorylation PhosphoSitePlus
Y35 Phosphorylation PhosphoSitePlus
S59 O-Glycosylation GlyGen 30379171, 31492838, 35254053, ...35132862, 28657654
T68 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
S161 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S162 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S174 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
T179 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus   UniProt 24275569
S193 Phosphorylation PhosphoSitePlus   UniProt 24275569
T198 Phosphorylation PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
S208 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T209 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S210 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S258 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
T290 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
Y617 Phosphorylation IEDB 35494241
K664 Ubiquitination PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
T675 Phosphorylation PhosphoSitePlus
T676 Phosphorylation PhosphoSitePlus
K787 Ubiquitination PhosphoSitePlus
K797 Ubiquitination PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
T955 Phosphorylation PhosphoSitePlus
Y980 Phosphorylation PhosphoSitePlus
Y982 Phosphorylation PhosphoSitePlus
Y1041 Phosphorylation PhosphoSitePlus
Y1048 Phosphorylation PhosphoSitePlus
S1055 Phosphorylation PhosphoSitePlus
Y1056 Phosphorylation PhosphoSitePlus
K1059 Ubiquitination PhosphoSitePlus
S1073 Phosphorylation PhosphoSitePlus
K1074 Ubiquitination PhosphoSitePlus
S1078 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1087 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1114 O-Glycosylation GlyGen 30379171, 31492838, 30620550, ...35132862, 35254053, 28657654
S1116 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1127 Phosphorylation PhosphoSitePlus
S1130 Phosphorylation PhosphoSitePlus
Y1133 Phosphorylation PhosphoSitePlus
T1135 O-Glycosylation GlyGen 30379171, 31492838, 35254053, ...35132862, 28657654
T1135 Phosphorylation PhosphoSitePlus
S1144 Phosphorylation PhosphoSitePlus
S1149 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1151 Phosphorylation PhosphoSitePlus
S1161 Phosphorylation PhosphoSitePlus
Y1166 Phosphorylation PhosphoSitePlus
K1169 Ubiquitination PhosphoSitePlus
S1170 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1178 O-Glycosylation GlyGen 30379171, 31492838, 35254053, ...35132862, 28657654
S1178 Phosphorylation PhosphoSitePlus
S1181 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1184 Phosphorylation PhosphoSitePlus
T1190 Phosphorylation PhosphoSitePlus
S1192 Phosphorylation PhosphoSitePlus
S1197 Phosphorylation PhosphoSitePlus
K1199 Ubiquitination PhosphoSitePlus
S1200 Phosphorylation PhosphoSitePlus
T1201 Phosphorylation PhosphoSitePlus
S1203 Phosphorylation PhosphoSitePlus
S1218 Phosphorylation PhosphoSitePlus
Y1219 Phosphorylation PhosphoSitePlus
S1255 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1257 Phosphorylation phospho.ELM 17081983
S1270 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 20068231
S1283 Phosphorylation PhosphoSitePlus
S1349 Phosphorylation neXtProt   PhosphoSitePlus 21382555
S1349 Phosphorylation Q9NYY3 (PLK2) neXtProt 21382555
S1365 Phosphorylation PhosphoSitePlus
S1366 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1367 Phosphorylation PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
T1388 Phosphorylation PhosphoSitePlus
S1390 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1391 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1393 Phosphorylation PhosphoSitePlus
S1404 Phosphorylation PhosphoSitePlus
T1405 Phosphorylation PhosphoSitePlus
T1408 O-Glycosylation GlyGen 30379171, 31492838, 35254053, ...35132862, 28657654
T1408 Phosphorylation PhosphoSitePlus
N1411 N-Glycosylation GlyGen 29671580
S1412 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1413 Phosphorylation PhosphoSitePlus
S1424 O-Glycosylation GlyGen 30379171, 31492838, 35254053, ...35132862, 28657654
S1428 Phosphorylation PhosphoSitePlus
S1431 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1433 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 20068231
T1438 Phosphorylation PhosphoSitePlus
S1439 Phosphorylation PhosphoSitePlus
S1442 Phosphorylation PhosphoSitePlus
S1443 Phosphorylation PhosphoSitePlus
S1454 Phosphorylation PhosphoSitePlus
S1468 Phosphorylation PhosphoSitePlus
S1496 Phosphorylation PhosphoSitePlus
S1508 Phosphorylation PhosphoSitePlus
S1521 Phosphorylation PhosphoSitePlus
S1528 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S1549 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 24275569, 19690332, 20068231
T1551 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S1554 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1557 Phosphorylation PhosphoSitePlus
S1564 Phosphorylation PhosphoSitePlus
S1565 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S1568 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S1572 Phosphorylation PhosphoSitePlus
T1573 Phosphorylation PhosphoSitePlus
T1575 Phosphorylation PhosphoSitePlus
S1576 Phosphorylation PhosphoSitePlus
T1583 Phosphorylation PhosphoSitePlus
S1585 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...15302935, 18669648, 24275569, 19690332
S1588 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1590 Phosphorylation PhosphoSitePlus
S1603 Phosphorylation PhosphoSitePlus
Y1619 Phosphorylation PhosphoSitePlus
S1621 Phosphorylation PhosphoSitePlus
S1625 Phosphorylation PhosphoSitePlus
S1632 Phosphorylation IntAct   PhosphoSitePlus 22117215
Y1633 Phosphorylation PhosphoSitePlus
T1634 Phosphorylation PhosphoSitePlus
S1639 Phosphorylation PhosphoSitePlus
S1645 Phosphorylation PhosphoSitePlus
S1647 Phosphorylation PhosphoSitePlus
S1649 Phosphorylation PhosphoSitePlus
S1650 Phosphorylation PhosphoSitePlus
Y1689 Phosphorylation PhosphoSitePlus
S1708 Phosphorylation PhosphoSitePlus
S1711 Phosphorylation PhosphoSitePlus
S1713 Phosphorylation PhosphoSitePlus
Y1727 Phosphorylation PhosphoSitePlus
S1730 Phosphorylation PhosphoSitePlus
S1733 Phosphorylation PhosphoSitePlus
S1734 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
T1736 Phosphorylation PhosphoSitePlus
S1739 Phosphorylation PhosphoSitePlus
K1789 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S161 Phosphorylation HPRD 19664995
S162 Phosphorylation HPRD 19664995
S208 Phosphorylation HPRD 18669648
T209 Phosphorylation HPRD 18669648
T239 Phosphorylation HPRD 18491316
S310 Phosphorylation HPRD 17081983
S894 Phosphorylation HPRD 20068231
T912 Phosphorylation HPRD 20068231
Y1133 Phosphorylation HPRD 20068231
S1149 Phosphorylation HPRD 19691289
T1190 Phosphorylation HPRD 18077418
S1255 Phosphorylation HPRD 18691976, 18669648, 20068231
S1257 Phosphorylation HPRD 17081983
S1270 Phosphorylation HPRD 18691976, 17081983, 20068231, ...19691289
S1349 Phosphorylation HPRD 20058876
N1411 N-Glycosylation PRO 29671580
S1433 Phosphorylation HPRD 17081983, 20068231, 19691289
S1528 Phosphorylation HPRD 17081983
S1549 Phosphorylation HPRD 19413330, 18691976, 17081983, ...20058876, 19664994, 19664995, 18452278, 18669648, 18707149, 20166139, 20068231, 19691289
T1551 Phosphorylation HPRD 19413330, 17081983, 20068231, ...19664995
S1554 Phosphorylation HPRD 20068231
S1565 Phosphorylation HPRD 20068231
S1568 Phosphorylation HPRD 20068231
S1585 Phosphorylation HPRD 19413330, 18691976, 20058876, ...19664994, 15302935, 19664995, 18452278, 18669648, 20166139, 19691289
S1708 Phosphorylation HPRD 17081983, 20068231
S1711 Phosphorylation HPRD 20068231
S1713 Phosphorylation HPRD 17081983
Y1727 Phosphorylation HPRD 19413330
S1730 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S1207 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T9 I9 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S59 R59 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S129 L129 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S174 N174 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S174 C174 Biomuta DOID:1324 / lung cancer [ icgc ]
S286 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S318 L318 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S364 F364 Biomuta DOID:4159 / skin cancer [ cosmic ]
S364 C364 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S397 G397 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S399 N399 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y617 H617 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K664 E664 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S667 Y667 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K819 N819 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S894 G894 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T912 A912 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T912 I912 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1055 L1055 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1073 N1073 Biomuta [ cosmic ]
K1074 N1074 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1078 L1078 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1087 R1087 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1114 R1114 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1116 F1116 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1144 F1144 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1151 T1151 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1170 F1170 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1170 P1170 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1190 I1190 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1201 M1201 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
S1270 F1270 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1371 F1371 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1390 F1390 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1404 L1404 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1413 I1413 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1428 P1428 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1428 F1428 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1439 N1439 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ]
S1443 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S1468 F1468 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1496 F1496 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1496 T1496 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1508 N1508 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1554 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1572 I1572 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1573 I1573 Biomuta DOID:363 / uterine cancer [ cosmic ]
S1585 L1585 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1585 P1585 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1625 L1625 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1634 A1634 Biomuta DOID:1319 / brain cancer [ icgc ]
S1639 L1639 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1639 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1647 L1647 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S1649 I1649 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1711 F1711 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1727 C1727 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1730 C1730 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1739 Y1739 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]