iPTMnet Report for O43164 (PJA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43164 / PJA2_HUMAN
Protein Name E3 ubiquitin-protein ligase Praja-2
Gene Name Name: PJA2
Synonyms:KIAA0438,RNF131;
Organism Homo sapiens (Human)

PRO ID PR:O43164
DAG View
PRO Name E3 ubiquitin-protein ligase Praja-2 (human)
Definition An E3 ubiquitin-protein ligase Praja-2 that is encoded in the genome of human.
Short Label hPJA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43164 (PJA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
Y4 Phosphorylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
Y28 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
Y42 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K46 Methylation PhosphoSitePlus
C48 Methylation IEDB 31844290
Y63 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
C151 Methylation IEDB 31844290
S167 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y212 Phosphorylation PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus   UniProt 24275569
S253 Phosphorylation PhosphoSitePlus   UniProt 23186163
K268 Ubiquitination PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K317 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
S323 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S324 Phosphorylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus   UniProt 21423175
S342 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 21423175
Y367 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S381 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T385 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T389 Phosphorylation PhosphoSitePlus   UniProt 21423175
T389 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 21423175
S396 Phosphorylation PhosphoSitePlus
S428 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S429 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S432 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S452 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
T460 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y4 Phosphorylation HPRD 20068231
S79 Phosphorylation HPRD 20068231
S235 Phosphorylation HPRD 19664994
S309 Phosphorylation HPRD 19651622, 20068231
S323 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y28 N28 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T30 A30 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K46 N46 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
C48 W48 Biomuta DOID:4159 / skin cancer [ cosmic ]
S79 F79 Biomuta DOID:4159 / skin cancer [ cosmic ]
S253 G253 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S282 L282 Biomuta DOID:4159 / skin cancer [ cosmic ]
S309 F309 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K320 Q320 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S323 R323 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S452 F452 Biomuta DOID:4159 / skin cancer [ cosmic ]
T460 I460 Biomuta DOID:4159 / skin cancer [ cosmic ]
S596 F596 Biomuta DOID:2531 / hematologic cancer [ cosmic ]