iPTMnet Report for O43159 (RRP8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43159 / RRP8_HUMAN
Protein Name Ribosomal RNA-processing protein 8
Gene Name Name: RRP8
Synonyms:KIAA0409,NML;ORFNames:hucep-1;
Organism Homo sapiens (Human)

PRO ID PR:O43159
DAG View
PRO Name ribosomal RNA-processing protein 8 (human)
Definition A ribosomal RNA-processing protein 8 that is encoded in the genome of human.
Short Label hRRP8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43159 (RRP8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T43 Phosphorylation PhosphoSitePlus
S51 Phosphorylation HPRD 17081983
S53 Phosphorylation HPRD   PhosphoSitePlus 17081983
S58 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
S62 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17081983, 18220336, ...18452278, 18669648, 19690332, 19415658, 20068231
S64 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17081983, 18220336, ...18452278, 18669648, 19690332, 19415658, 20068231
K78 Acetylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
S104 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983
S106 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17081983, 19691289
S124 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17287340, 19691289
S126 O-Glycosylation GlyGen 23301498, 33465208
S126 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17287340, 19007248, ...19691289, 20068231
K157 Sumoylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus
S171 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569, ...16565220
S174 O-Glycosylation GlyGen 23301498, 33465208
S174 Phosphorylation HPRD   PhosphoSitePlus 20068231
T175 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S176 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...16565220
S184 Phosphorylation HPRD   phospho.ELM 17081983
K201 Sumoylation PhosphoSitePlus
S223 O-Glycosylation GlyGen 23301498, 33465208
S223 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 19691289, ...16565220, 19651622, 18669648, 20068231
S286 Phosphorylation PhosphoSitePlus
R401 Methylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K440 Sumoylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K454 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S62 G62 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S83 C83 Biomuta DOID:4159 / skin cancer [ cosmic ]
S106 P106 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S124 N124 Biomuta DOID:3571 / liver cancer [ cosmic ]
S162 N162 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S176 F176 Biomuta DOID:1319 / brain cancer [ icgc ]
S223 P223 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R401 Q401 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K440 N440 Biomuta DOID:363 / uterine cancer [ icgc ]