iPTMnet Report for O43149 (ZZEF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43149 / ZZEF1_HUMAN
Protein Name Zinc finger ZZ-type and EF-hand domain-containing protein 1
Gene Name Name: ZZEF1
Synonyms:KIAA0399;
Organism Homo sapiens (Human)

PRO ID PR:O43149
DAG View
PRO Name zinc finger ZZ-type and EF-hand domain-containing protein 1 (human)
Definition A zinc finger ZZ-type and EF-hand domain-containing protein 1 that is encoded in the genome of human.
Short Label hZZEF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43149 (ZZEF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 24223779, 20213681
K220 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus   UniProt 23186163
K245 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K523 Acetylation PhosphoSitePlus
K526 Acetylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
K543 Acetylation PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
Y702 Phosphorylation PhosphoSitePlus
T723 Phosphorylation PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
Y976 Phosphorylation PhosphoSitePlus
K1078 Ubiquitination PhosphoSitePlus
K1158 Ubiquitination PhosphoSitePlus
K1251 Ubiquitination PhosphoSitePlus
S1267 Phosphorylation PhosphoSitePlus
S1276 Phosphorylation PhosphoSitePlus
K1357 Ubiquitination PhosphoSitePlus
S1368 Phosphorylation PhosphoSitePlus
K1391 Ubiquitination PhosphoSitePlus
K1458 Ubiquitination PhosphoSitePlus
T1462 Phosphorylation PhosphoSitePlus
S1463 Phosphorylation PhosphoSitePlus
S1464 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1475 Phosphorylation PhosphoSitePlus   UniProt 19690332
T1477 Phosphorylation PhosphoSitePlus
T1484 Phosphorylation PhosphoSitePlus
S1488 Phosphorylation PhosphoSitePlus
T1493 Phosphorylation PhosphoSitePlus
S1499 Phosphorylation PhosphoSitePlus
S1501 Phosphorylation PhosphoSitePlus
S1509 O-Glycosylation GlyGen 30379171, 29351928
S1509 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243
T1512 O-Glycosylation GlyGen 30379171, 29351928
T1512 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S1518 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243
S1520 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1521 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1523 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1529 Phosphorylation PhosphoSitePlus
S1537 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1540 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1565 Ubiquitination PhosphoSitePlus
S1568 Phosphorylation PhosphoSitePlus
K1765 Ubiquitination PhosphoSitePlus
S1801 Phosphorylation PhosphoSitePlus
S2049 Phosphorylation PhosphoSitePlus
T2074 Phosphorylation PhosphoSitePlus
K2087 Ubiquitination PhosphoSitePlus
K2291 Ubiquitination PhosphoSitePlus
K2299 Ubiquitination PhosphoSitePlus
T2374 Phosphorylation PhosphoSitePlus
S2443 Phosphorylation PhosphoSitePlus
S2444 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2490 Ubiquitination PhosphoSitePlus
K2491 Ubiquitination PhosphoSitePlus
Y2494 Phosphorylation PhosphoSitePlus
K2501 Ubiquitination PhosphoSitePlus
K2525 Ubiquitination PhosphoSitePlus
S2526 Phosphorylation PhosphoSitePlus
K2566 Ubiquitination PhosphoSitePlus
K2581 Ubiquitination PhosphoSitePlus
K2586 Ubiquitination PhosphoSitePlus
K2593 Ubiquitination PhosphoSitePlus
K2667 Acetylation PhosphoSitePlus   UniProt 19608861
K2667 Ubiquitination PhosphoSitePlus
K2671 Ubiquitination PhosphoSitePlus
S2757 Phosphorylation PhosphoSitePlus
S2759 Phosphorylation PhosphoSitePlus
S2761 Phosphorylation PhosphoSitePlus
K2764 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1464 Phosphorylation HPRD 18669648
S1509 Phosphorylation HPRD 18669648, 16964243
T1512 Phosphorylation HPRD 18669648
S1518 Phosphorylation HPRD 19413330, 18669648, 16964243, ...20068231
S1520 Phosphorylation HPRD 19413330, 18669648
T1521 Phosphorylation HPRD 18669648
S1537 Phosphorylation HPRD 19651622
S1540 Phosphorylation HPRD 19651622
S2407 Phosphorylation HPRD 20068231
Y2411 Phosphorylation HPRD 20068231
S2444 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S240 N240 Biomuta DOID:4159 / skin cancer [ cosmic ]
K251 Q251 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K251 T251 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K526 E526 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1276 N1276 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1488 R1488 Biomuta [ cosmic ]
S1499 P1499 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1499 F1499 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1537 F1537 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1565 N1565 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S2407 P2407 Biomuta DOID:363 / uterine cancer [ icgc ]
K2501 N2501 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]
S2761 C2761 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]