iPTMnet Report for O43148 (RNMT)
Protein Information
UniProt AC / UniProt ID | O43148 / MCES_HUMAN |
Protein Name | mRNA cap guanine-N7 methyltransferase |
Gene Name | Name: RNMT Synonyms:KIAA0398; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O43148 |
PRO Name | mRNA cap guanine-N7 methyltransferase (human) |
Definition | An mRNA cap guanine-N7 methyltransferase that is encoded in the genome of human. |
Short Label | hRNMT |
Category | organism-gene |
O43148 (RNMT) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K6 | Acetylation | score1 | PhosphoSitePlus | |||
Y10 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 28981715 | ||
S39 | Phosphorylation | score1 | PhosphoSitePlus | |||
S44 | Phosphorylation | score1 | PhosphoSitePlus | |||
T77 | Phosphorylation | P06493 (CDK1) | score4 | PhosphoSitePlus RLIMS-P Signor | 27791484, 28981715, 26942677 | |
S79 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 26942677 | ||
C95 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
K126 | Acetylation | score1 | PhosphoSitePlus | |||
K128 | Acetylation | score1 | PhosphoSitePlus | |||
K128 | Ubiquitination | score1 | PhosphoSitePlus | |||
K137 | Acetylation | score1 | PhosphoSitePlus | |||
K137 | Ubiquitination | score1 | PhosphoSitePlus | |||
K139 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y153 | Phosphorylation | score1 | PhosphoSitePlus | |||
K163 | Ubiquitination | score1 | PhosphoSitePlus | |||
K180 | Methylation | score1 | PhosphoSitePlus | |||
K190 | Ubiquitination | score1 | PhosphoSitePlus | |||
K208 | Acetylation | score1 | PhosphoSitePlus | |||
K208 | Ubiquitination | score1 | PhosphoSitePlus | |||
K214 | Ubiquitination | score1 | PhosphoSitePlus | |||
K222 | Ubiquitination | score1 | PhosphoSitePlus | |||
K234 | Ubiquitination | score1 | PhosphoSitePlus | |||
C305 | Methylation | score1 | IEDB | 31844290 | ||
S331 | Phosphorylation | score1 | PhosphoSitePlus | |||
T333 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y341 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y385 | Phosphorylation | score1 | PhosphoSitePlus | |||
K393 | Ubiquitination | score1 | PhosphoSitePlus | |||
K428 | Ubiquitination | score1 | PhosphoSitePlus | |||
K433 | Acetylation | score1 | PhosphoSitePlus | |||
K433 | Ubiquitination | score1 | PhosphoSitePlus | |||
K442 | Ubiquitination | score1 | PhosphoSitePlus | |||
K445 | Ubiquitination | score1 | PhosphoSitePlus | |||
S447 | Phosphorylation | score1 | PhosphoSitePlus | |||
T455 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | O43148 (RNMT) | T77 | P52292 (KPNA2) | unknown | eFIP | 26942677 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K128 | N128 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
K163 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
S232 | F232 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
Y341 | C341 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K445 | Q445 | Biomuta | DOID:2998 / testicular cancer [ cosmic ] |