iPTMnet Report for O43148 (RNMT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43148 / MCES_HUMAN
Protein Name mRNA cap guanine-N7 methyltransferase
Gene Name Name: RNMT
Synonyms:KIAA0398;
Organism Homo sapiens (Human)

PRO ID PR:O43148
DAG View
PRO Name mRNA cap guanine-N7 methyltransferase (human)
Definition An mRNA cap guanine-N7 methyltransferase that is encoded in the genome of human.
Short Label hRNMT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43148 (RNMT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation PhosphoSitePlus
Y10 Phosphorylation PhosphoSitePlus   RLIMS-P 28981715
S39 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
T77 Phosphorylation P06493 (CDK1) PhosphoSitePlus   RLIMS-P   Signor 27791484, 28981715, 26942677
S79 Phosphorylation PhosphoSitePlus   RLIMS-P 26942677
C95 S-Nitrosylation dbSNO 26338901
K126 Acetylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K137 Acetylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K180 Methylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
C305 Methylation IEDB 31844290
S331 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
Y341 Phosphorylation PhosphoSitePlus
Y385 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K433 Acetylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S232 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43148 (RNMT) T77 P52292 (KPNA2) unknown eFIP 26942677


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K128 N128 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K163 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S232 F232 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y341 C341 Biomuta DOID:363 / uterine cancer [ icgc ]
K445 Q445 Biomuta DOID:2998 / testicular cancer [ cosmic ]