iPTMnet Report for O35346 (Ptk2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O35346 / FAK1_RAT
Protein Name Focal adhesion kinase 1
Gene Name Name: Ptk2
Synonyms:Fak,Fak1;
Organism Rattus norvegicus (Rat)

PRO ID PR:O35346
DAG View
PRO Name focal adhesion kinase 1 (rat)
Definition A focal adhesion kinase 1 that is encoded in the genome of rat.
Short Label rPTK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O35346 (Ptk2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
K152 Sumoylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation O35346 (Ptk2) PhosphoSitePlus   RLIMS-P   UniProt 32592615, 33920786, 19470782, ...11882598, 33692398, 30853931, 15096502, 19364917, 18539755, 16825486, 14500712, 24884636, 15537746, 12391143, 28744198, 22900166, 16618703, 16195476, 29018403, 24772088, 22276220, 10794722, 24217647, 15817454, 22654119, 17003277, 9374543, 25300309, 34194565, 19880666, 15923313, 23118988, 19361463, 21357465, 30187999, 31784544, 22914642, 9353341, 9334354, 32352989, 17549512, 21246051, 15930288, 30510582, 26018803, 12732587, 12805241
Y407 Phosphorylation PhosphoSitePlus   RLIMS-P 22797892, 24169556, 17976369
S568 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
T575 Phosphorylation PhosphoSitePlus
Y576 Phosphorylation Q07014 (Lyn) , Q9WUD9 (Src) PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 30355914, 10848597, 22673903, ...22006118, 16547166
Y577 Phosphorylation Q07014 (Lyn) PhosphoSitePlus   RLIMS-P 30355914, 10848597, 15451029
S580 Phosphorylation PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 12732587
S732 Phosphorylation RLIMS-P 21378178
K834 Acetylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus   RLIMS-P 17240116
Y861 Phosphorylation PhosphoSitePlus   RLIMS-P 16547166
S913 Phosphorylation PhosphoSitePlus   UniProt 22673903, 12732587
Y928 Phosphorylation PhosphoSitePlus   UniProt 22673903
Site PTM Type PTM Enzyme Score Source PMID
Y397 Phosphorylation PRO 27994061
Y576 Phosphorylation PRO 27994061
Y577 Phosphorylation PRO 27994061
Y928 Phosphorylation PRO 27994061


O35346 (Ptk2) as PTM Enzyme



Substrate Site Score Source PMID
O35346 (Ptk2) Y397 PhosphoSitePlus   UniProt 12391143, 10794722, 14500712
Q63767 (Bcar1) Y263 PhosphoSitePlus 9360983
Q63767 (Bcar1) Y762 PhosphoSitePlus 9360983
Q63767 (Bcar1) Y764 PhosphoSitePlus 9360983


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049946 (rPTK2/iso:1/Phos:1) pY397 PRO 27994061
PR:000049948 (rPTK2/iso:1/Phos:2) pY576,pY577 PRO 27994061
PR:000049950 (rPTK2/iso:1/Phos:3) pY928 PRO 27994061


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O35346 (Ptk2) Y397 Q9WUD9 (Src) unknown eFIP 19364917