iPTMnet Report for O15553 (MEFV)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15553 / MEFV_HUMAN
Protein Name Pyrin
Gene Name Name: MEFV
Synonyms:MEF,TRIM20;
Organism Homo sapiens (Human)

PRO ID PR:O15553
DAG View
PRO Name pyrin (human)
Definition A pyrin that is encoded in the genome of human.
Short Label hMEFV
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15553 (MEFV) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
T12 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
R151 Methylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus   RLIMS-P 32601469
S209 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27030597, 32601469, 31589380
T267 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
K380 Acetylation PhosphoSitePlus
K431 Acetylation PhosphoSitePlus
K432 Acetylation PhosphoSitePlus
S442 O-Glycosylation GlyGen 29351928
T672 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
Y732 Phosphorylation PhosphoSitePlus
Y741 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 G6 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S141 N141 Biomuta DOID:363 / uterine cancer [ icgc ]
S209 F209 Biomuta DOID:4159 / skin cancer [ cosmic ]
S273 L273 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S363 N363 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S442 F442 Biomuta DOID:4159 / skin cancer [ cosmic ]
S673 P673 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S673 Y673 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]