iPTMnet Report for O15534 (PER1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15534 / PER1_HUMAN
Protein Name Period circadian protein homolog 1
Gene Name Name: PER1
Synonyms:KIAA0482,PER,RIGUI;
Organism Homo sapiens (Human)

PRO ID PR:O15534
DAG View
PRO Name period circadian protein homolog 1 (human)
Definition A period circadian protein homolog 1 that is encoded in the genome of human.
Short Label hPER1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15534 (PER1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Ubiquitination PRO
S27 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
T319 O-Glycosylation GlyGen 30379171, 35254053
T323 O-Glycosylation GlyGen 30379171, 35254053
K324 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
R576 Methylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
C641 Methylation IEDB 31844290
S645 Phosphorylation PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
Y657 Phosphorylation PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
T692 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
T702 Phosphorylation PhosphoSitePlus
S704 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S714 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
R803 Methylation PhosphoSitePlus
R805 Methylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
T812 Phosphorylation PhosphoSitePlus
S815 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S830 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
R892 Methylation PhosphoSitePlus
S979 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S980 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
K1096 Acetylation PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus
S1103 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
S1186 Phosphorylation PhosphoSitePlus
S1262 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1263 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1276 Phosphorylation PhosphoSitePlus
S1279 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T161 Phosphorylation HPRD 20068231
T164 Phosphorylation HPRD 20068231
S704 Phosphorylation HPRD 19413330, 18669648, 20068231
S815 Phosphorylation HPRD 18669648
S979 Phosphorylation HPRD 17081983
S980 Phosphorylation HPRD 17081983
S1100 Phosphorylation HPRD 19651622, 17081983
S1103 Phosphorylation HPRD 19651622, 17081983
S1104 Phosphorylation HPRD 19651622, 17081983
S1186 Phosphorylation HPRD 18491316
S1262 Phosphorylation HPRD 17525332
S1263 Phosphorylation HPRD 17525332
S1279 Phosphorylation HPRD 19664995


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048745 (hPER1/PhosSer+) p PRO
PR:000048746 (hPER1/pSerUbiq+) p PRO
PR:000048746 (hPER1/pSerUbiq+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S27 F27 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S27 Y27 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T164 M164 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R576 C576 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S654 P654 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R803 M803 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R805 H805 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S811 F811 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S830 I830 Biomuta DOID:1319 / brain cancer [ icgc ]
K1096 T1096 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]