iPTMnet Report for O15530 (PDPK1)
Protein Information
UniProt AC / UniProt ID | O15530 / PDPK1_HUMAN |
Protein Name | 3-phosphoinositide-dependent protein kinase 1 |
Gene Name | Name: PDPK1 Synonyms:PDK1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O15530 |
PRO Name | 3-phosphoinositide-dependent protein kinase 1 (human) |
Definition | A 3-phosphoinositide-dependent protein kinase 1 that is encoded in the genome of human. |
Short Label | hPDPK1 |
Category | organism-gene |
O15530 (PDPK1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T5 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S6 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
Y9 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 11481331, 16314505, 15302935, ... | ||
Y9 | Phosphorylation | P07949 (RET) | score3 | neXtProt phospho.ELM PhosphoSitePlus | 12738763 | |
Y9 | Phosphorylation | P12931 (SRC) | score4 | neXtProt phospho.ELM Signor | 11481331, 14585963 | |
S22 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S22 | Phosphorylation | score1 | PhosphoSitePlus | |||
S25 | Phosphorylation | score3 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 10455013 | ||
S25 | Phosphorylation | O15530 (PDPK1) | score3 | PhosphoSitePlus Signor | 10455013 | |
T33 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 11481331 | ||
T33 | Phosphorylation | P12931 (SRC) | score2 | neXtProt | 11481331 | |
S36 | Phosphorylation | score1 | PhosphoSitePlus | |||
T37 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S45 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S45 | Phosphorylation | score1 | PhosphoSitePlus | |||
S64 | Phosphorylation | score1 | PhosphoSitePlus | |||
K83 | Ubiquitination | score1 | PhosphoSitePlus | |||
S92 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S92 | Phosphorylation | score1 | PhosphoSitePlus | |||
S105 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
K111 | Ubiquitination | score1 | PhosphoSitePlus | |||
K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
T148 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y156 | Phosphorylation | score1 | PhosphoSitePlus | |||
S160 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y161 | Phosphorylation | score1 | PhosphoSitePlus | |||
S176 | Phosphorylation | score1 | PhosphoSitePlus | |||
T180 | Phosphorylation | score1 | PhosphoSitePlus | |||
C181 | Methylation | score1 | IEDB | 31844290 | ||
T222 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S231 | Phosphorylation | score1 | PhosphoSitePlus | |||
S234 | Phosphorylation | score1 | PhosphoSitePlus | |||
K235 | Ubiquitination | score1 | PhosphoSitePlus | |||
S241 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 21565140, 12177059, 10455013, ... | ||
S241 | Phosphorylation | O15530 (PDPK1) | score4 | neXtProt PhosphoSitePlus Signor UniProt | 12177059, 16780920, 10455013, ... | |
T245 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17081983 | ||
Y248 | Phosphorylation | score1 | PhosphoSitePlus | |||
S250 | Phosphorylation | score1 | PhosphoSitePlus | |||
T255 | Phosphorylation | score1 | PhosphoSitePlus | |||
K257 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y288 | Phosphorylation | score1 | PhosphoSitePlus | |||
K304 | Acetylation | score1 | PhosphoSitePlus | |||
K304 | Ubiquitination | score1 | PhosphoSitePlus | |||
K315 | Ubiquitination | score1 | PhosphoSitePlus | |||
K323 | Ubiquitination | score1 | PhosphoSitePlus | |||
K337 | Ubiquitination | score1 | PhosphoSitePlus | |||
T354 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
T354 | Phosphorylation | score3 | neXtProt PhosphoSitePlus UniProt | 22544756 | ||
T354 | Phosphorylation | Q14680 (MELK) | score2 | neXtProt | 22544756 | |
S366 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S366 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y373 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 11481331, 16314505, 15302935, ... | ||
Y373 | Phosphorylation | P08069 (IGF1R) | score4 | PhosphoSitePlus Signor | 20044479, 20643654 | |
Y373 | Phosphorylation | P12931 (SRC) | score4 | phospho.ELM PhosphoSitePlus Signor | 18024423, 11054117, 20643654, ... | |
Y376 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 11481331, 16314505, 15302935, ... | ||
Y376 | Phosphorylation | P08069 (IGF1R) | score4 | PhosphoSitePlus Signor | 20044479, 20643654 | |
Y376 | Phosphorylation | P12931 (SRC) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 18024423, 20643654, 11481331, ... | |
S381 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S390 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S392 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S393 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 10455013 | ||
S393 | Phosphorylation | O15530 (PDPK1) | score3 | PhosphoSitePlus Signor | 10455013 | |
S394 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S394 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 19920149, 22544756 | ||
S394 | Phosphorylation | Q99683 (MAP3K5) | score4 | neXtProt PhosphoSitePlus | 19920149, 22544756 | |
S396 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S396 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 15743829, 10455013 | ||
S396 | Phosphorylation | O15530 (PDPK1) | score4 | PhosphoSitePlus Signor | 15743829, 10455013 | |
S398 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 19920149, 22544756 | ||
S398 | Phosphorylation | Q99683 (MAP3K5) | score4 | neXtProt PhosphoSitePlus | 19920149, 22544756 | |
S400 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
T402 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S408 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
S410 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 10455013, 11481331 | ||
S410 | Phosphorylation | O15530 (PDPK1) | score3 | PhosphoSitePlus Signor | 10455013 | |
S423 | O-Glycosylation | score1 | GlyGen | 36580660 | ||
K441 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y485 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 11481331 | ||
Y485 | Phosphorylation | P12931 (SRC) | score2 | neXtProt | 11481331 | |
Y486 | Phosphorylation | score1 | PhosphoSitePlus | |||
K495 | Ubiquitination | score1 | PhosphoSitePlus | |||
S501 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 19047061 | ||
S501 | Phosphorylation | Q04759 (PRKCQ) | score2 | neXtProt | 19047061 | |
K509 | Ubiquitination | score1 | PhosphoSitePlus | |||
T513 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 16780920, 11481331 | ||
T513 | Phosphorylation | O15530 (PDPK1) | score3 | PhosphoSitePlus UniProt | 16780920 | |
T513 | Phosphorylation | P12931 (SRC) | score2 | neXtProt | 11481331 | |
S529 | Phosphorylation | score2 | neXtProt | 19047061 | ||
S529 | Phosphorylation | O15530 (PDPK1) | score2 | neXtProt | 19047061 | |
S529 | Phosphorylation | Q04759 (PRKCQ) | score2 | neXtProt | 19047061 | |
K534 | Acetylation | score1 | PhosphoSitePlus | |||
S549 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y9 | Phosphorylation | score1 | HPRD | 11481331 | ||
Y9 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 11481331 | |
S25 | Phosphorylation | score1 | HPRD | 10455013 | ||
T33 | Phosphorylation | score1 | HPRD | 11481331 | ||
T33 | Phosphorylation | O15530 (PDPK1) | score1 | HPRD | 11481331 | |
T37 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 18669648 | ||
S241 | Phosphorylation | score2 | HPRD | 19413330, 18691976, 10455013, ... | ||
S241 | Phosphorylation | O15530 (PDPK1) | score2 | HPRD | 19413330, 18691976, 10455013, ... | |
T245 | Phosphorylation | score0 | HPRD | 17081983 | ||
Y373 | Phosphorylation | score1 | HPRD | 11481331 | ||
Y373 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 11481331 | |
S393 | Phosphorylation | score1 | HPRD | 10455013 | ||
S396 | Phosphorylation | score1 | HPRD | 10455013 | ||
S410 | Phosphorylation | score1 | HPRD | 10455013 | ||
Y485 | Phosphorylation | score1 | HPRD | 11481331 | ||
Y485 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 11481331 | |
S501 | Phosphorylation | score0 | HPRD | 19664994 | ||
T513 | Phosphorylation | score1 | HPRD | 11481331 | ||
T513 | Phosphorylation | O15530 (PDPK1) | score1 | HPRD | 11481331 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y9 | Phosphorylation | score1 | HPRD | 11481331 | ||
Y9 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 11481331 | |
S25 | Phosphorylation | score1 | HPRD | 10455013 | ||
T33 | Phosphorylation | score1 | HPRD | 11481331 | ||
T33 | Phosphorylation | O15530 (PDPK1) | score1 | HPRD | 11481331 | |
T37 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 19413330, 18691976, 18669648 | ||
S114 | Phosphorylation | score4 | HPRD PhosphoSitePlus | 19413330, 10455013, 20230923, ... | ||
S114 | Phosphorylation | O15530 (PDPK1) | score2 | HPRD | 19413330, 18691976, 10455013, ... | |
T118 | Phosphorylation | score0 | HPRD | 17081983 | ||
Y246 | Phosphorylation | score1 | HPRD | 11481331 | ||
Y246 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 11481331 | |
S266 | Phosphorylation | score1 | HPRD | 10455013 | ||
S269 | Phosphorylation | score1 | HPRD | 10455013 | ||
S283 | Phosphorylation | score1 | HPRD | 10455013 | ||
K314 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y358 | Phosphorylation | score1 | HPRD | 11481331 | ||
Y358 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 11481331 | |
S374 | Phosphorylation | score0 | HPRD | 19664994 | ||
T386 | Phosphorylation | score1 | HPRD | 11481331 | ||
T386 | Phosphorylation | O15530 (PDPK1) | score1 | HPRD | 11481331 | |
K407 | Acetylation | score1 | PhosphoSitePlus |
O15530 (PDPK1) as PTM Enzyme
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | O15530 (PDPK1) | Y9 | P12931 (SRC) | unknown | eFIP | 18024423 | |
Phosphorylation | P31749 (AKT1) | T308 | O15530 (PDPK1) | unknown | eFIP | 19402821 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S64 | F64 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
S92 | F92 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
Y248 | H248 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S250 | Y250 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S381 | N381 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
T386 | S386 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S390 | L390 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] | |
S394 | L394 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S398 | L398 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
S400 | Y400 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
T402 | K402 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T513 | S513 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S549 | N549 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |