iPTMnet Report for O15527 (OGG1)
Protein Information
UniProt AC / UniProt ID | O15527 / OGG1_HUMAN |
Protein Name | N-glycosylase/DNA lyase |
Gene Name | Name: OGG1 Synonyms:MMH,MUTM,OGH1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O15527 |
PRO Name | N-glycosylase/DNA lyase (human) |
Definition | An N-glycosylase/DNA lyase that is encoded in the genome of human. |
Short Label | hOGG1 |
Category | organism-gene |
O15527 (OGG1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S115 | Phosphorylation | score1 | PhosphoSitePlus | |||
S183 | Phosphorylation | score1 | PhosphoSitePlus | |||
K198 | Ubiquitination | score1 | PhosphoSitePlus | |||
S231 | Phosphorylation | score1 | PhosphoSitePlus | |||
S232 | Phosphorylation | score1 | PhosphoSitePlus | |||
S280 | Phosphorylation | score1 | PhosphoSitePlus | |||
K289 | Ubiquitination | score1 | PhosphoSitePlus | |||
K297 | Ubiquitination | score1 | PhosphoSitePlus | |||
S326 | Phosphorylation | score1 | PhosphoSitePlus | |||
K338 | Acetylation | score1 | PhosphoSitePlus | |||
K341 | Acetylation | score1 | PhosphoSitePlus | |||
K341 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K338 | Acetylation | score2 | PRO | 16478987 | ||
K338 | Acetylation | PR:000007102 (EP300) | score2 | PRO | 16478987 | |
K341 | Acetylation | score2 | PRO | 16478987 | ||
K341 | Acetylation | PR:000007102 (EP300) | score2 | PRO | 16478987 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000028600 (hOGG1/iso:1/Ac:1) | acK338,acK341 | PR:000007102 (EP300) | PRO | 16478987 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S115 | F115 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S326 | C326 | Biomuta | [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ] | |
K338 | E338 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |