iPTMnet Report for O15523 (DDX3Y)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15523 / DDX3Y_HUMAN
Protein Name ATP-dependent RNA helicase DDX3Y
Gene Name Name: DDX3Y
Synonyms:DBY;
Organism Homo sapiens (Human)

PRO ID PR:O15523
DAG View
PRO Name ATP-dependent RNA helicase DDX3Y (human)
Definition An ATP-dependent RNA helicase DDX3Y that is encoded in the genome of human.
Short Label hDDX3Y
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15523 (DDX3Y) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K25 Ubiquitination PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
K66 Methylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
Y69 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S70 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
R75 Methylation PhosphoSitePlus
R78 Methylation PhosphoSitePlus
R87 Methylation PhosphoSitePlus
R92 Methylation PhosphoSitePlus
R98 Methylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
Y198 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
Y299 Phosphorylation PhosphoSitePlus
R313 Methylation PhosphoSitePlus
C315 S-Nitrosylation dbSNO 19483679
T321 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
K333 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
Y341 Phosphorylation phospho.ELM   PhosphoSitePlus 16097034
R360 Methylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
T436 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
Y460 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
R473 Methylation PhosphoSitePlus
R476 Methylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
Y574 Phosphorylation PhosphoSitePlus
Y578 Phosphorylation PhosphoSitePlus
R590 Methylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
R598 Methylation PhosphoSitePlus
Y600 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
R615 Methylation PhosphoSitePlus
R630 Methylation PhosphoSitePlus
Y637 Phosphorylation PhosphoSitePlus
Y650 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y69 Phosphorylation HPRD 15144186
S70 Phosphorylation HPRD 15570572
S592 Phosphorylation HPRD 18691976, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
K12 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R92 S92 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R98 C98 Biomuta DOID:4159 / skin cancer [ cosmic ]
S101 I101 Biomuta DOID:3571 / liver cancer [ cosmic, icgc, tcga ]
Y299 H299 Biomuta DOID:4159 / skin cancer [ cosmic ]
R313 H313 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K340 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
R476 K476 Biomuta DOID:1324 / lung cancer [ cosmic ]
S490 G490 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R590 T590 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
R598 T598 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]