iPTMnet Report for O15519 (CFLAR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15519 / CFLAR_HUMAN
Protein Name CASP8 and FADD-like apoptosis regulator precursor
Gene Name Name: CFLAR
Synonyms:CASH,CASP8AP1,CLARP,MRIT;
Organism Homo sapiens (Human)

PRO ID PR:O15519
DAG View
PRO Name CASP8 and FADD-like apoptosis regulator (human)
Definition A CASP8 and FADD-like apoptosis regulator that is encoded in the genome of human.
Short Label hCFLAR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15519 (CFLAR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K49 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
R122 Methylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus   RLIMS-P 23519470
K167 Ubiquitination PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
S193 Phosphorylation P17252 (PRKCA) , P05771 (PRKCB) PhosphoSitePlus   RLIMS-P 19343040
K195 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
C254 S-Nitrosylation dbSNO 16246840, 22178444
C259 S-Nitrosylation dbSNO 16246840, 22178444
S273 Phosphorylation P31749 (AKT1) PhosphoSitePlus   Signor 19339247
S314 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S193 Phosphorylation P05771 (PRKCB) , P17252 (PRKCA) PhosphoSitePlus 19343040


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R122 Q122 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K167 N167 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K214 E214 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S273 F273 Biomuta DOID:10534 / stomach cancer [ cosmic ]