iPTMnet Report for O15503 (INSIG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15503 / INSI1_HUMAN
Protein Name Insulin-induced gene 1 protein
Gene Name Name: INSIG1
Organism Homo sapiens (Human)

PRO ID PR:O15503
DAG View
PRO Name insulin-induced gene 1 protein (human)
Definition An insulin-induced gene 1 protein that is encoded in the genome of human.
Short Label hINSIG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15503 (INSIG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
C146 Methylation IEDB 31844290
K156 Ubiquitination PhosphoSitePlus   UniProt 16399501
K158 Ubiquitination PhosphoSitePlus   UniProt 16399501
C167 Methylation IEDB 31844290
S178 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus   UniProt 32322062
S209 Phosphorylation PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
C250 Methylation IEDB 31844290
K273 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S43 P43 Biomuta DOID:1319 / brain cancer [ cosmic ]
S178 N178 Biomuta [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T222 M222 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]