iPTMnet Report for O15484 (CAPN5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15484 / CAN5_HUMAN
Protein Name Calpain-5
Gene Name Name: CAPN5
Synonyms:NCL3;
Organism Homo sapiens (Human)

PRO ID PR:O15484
DAG View
PRO Name calpain-5 (human)
Definition A calpain-5 that is encoded in the genome of human.
Short Label hCAPN5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15484 (CAPN5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
Y254 Phosphorylation PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 L14 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y254 C254 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S449 T449 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S454 L454 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K565 Q565 Biomuta DOID:10534 / stomach cancer [ cosmic ]