iPTMnet Report for O15446 (POLR1G)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15446 / RPA34_HUMAN
Protein Name DNA-directed RNA polymerase I subunit RPA34
Gene Name Name: POLR1G
Synonyms:ASE1;
Organism Homo sapiens (Human)

PRO ID PR:O15446
DAG View
PRO Name DNA-directed RNA polymerase I subunit RPA34 (human)
Definition A DNA-directed RNA polymerase I subunit RPA34 that is encoded in the genome of human.
Short Label hPOLR1G
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15446 (POLR1G) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
S27 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S66 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y80 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16809778, 10373416
S124 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S126 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S128 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S136 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332
C150 S-Nitrosylation dbSNO 26338901
T159 Phosphorylation PhosphoSitePlus
R162 Methylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
T171 Phosphorylation PhosphoSitePlus
S172 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
K174 Acetylation PhosphoSitePlus
S205 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S248 Phosphorylation phospho.ELM 18669648
T249 Phosphorylation phospho.ELM 18669648
K270 Sumoylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
S285 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18234856, ...15302935, 18669648, 20068231
T287 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S309 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K314 Sumoylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
T419 Phosphorylation phospho.ELM 18669648
T421 Phosphorylation phospho.ELM 18669648
T456 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
T475 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus   UniProt 19690332
Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation HPRD 18669648
S64 Phosphorylation HPRD 20068231
S66 Phosphorylation HPRD 20068231
Y80 Phosphorylation HPRD 10373416
S124 Phosphorylation HPRD 18669648, 17081983
S126 Phosphorylation HPRD 18669648, 17081983
S128 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231, 19415658
S136 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231, 19415658
T171 Phosphorylation HPRD 20068231
S172 Phosphorylation HPRD 18669648, 16964243, 20068231, ...19664995
S205 Phosphorylation HPRD 18669648
S248 Phosphorylation HPRD 18669648, 20068231
T249 Phosphorylation HPRD 18669648, 20068231
T282 Phosphorylation HPRD 19664995, 20068231
S285 Phosphorylation HPRD 19413330, 20058876, 19664994, ...15302935, 19664995, 18452278, 18669648, 19415658, 20068231
T287 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19664995, 18452278, 18669648, 19415658
S309 Phosphorylation HPRD 17525332
S359 Phosphorylation HPRD 18452278
T419 Phosphorylation HPRD 18669648
T421 Phosphorylation HPRD 18669648
S488 Phosphorylation HPRD 19413330, 19664995, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S64 F64 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S163 T163 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S163 L163 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S205 L205 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T276 S276 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T363 A363 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]