Protein Information

Cytoscape View


UniProt AC / UniProt ID O15439 / MRP4_HUMAN
Protein Name Multidrug resistance-associated protein 4
Gene Name Name: ABCC4
Synonyms:MRP4;
Organism Homo sapiens (Human)

PRO ID PR:O15439
DAG View
PRO Name multidrug resistance-associated protein 4 (human)
Definition A multidrug resistance-associated protein 4 that is encoded in the genome of human.
Short Label hABCC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15439 (ABCC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y45 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
T388 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
T646 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
T648 Phosphorylation PhosphoSitePlus   UniProt 23186163
T653 Phosphorylation PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus   UniProt 23186163
S668 Phosphorylation PhosphoSitePlus   UniProt 23186163
K670 Ubiquitination PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
K807 Acetylation PhosphoSitePlus
K807 Ubiquitination PhosphoSitePlus
T913 Phosphorylation PhosphoSitePlus
K918 Ubiquitination PhosphoSitePlus
Y1016 Phosphorylation PhosphoSitePlus
K1021 Ubiquitination PhosphoSitePlus
K1066 Ubiquitination PhosphoSitePlus
K1070 Ubiquitination PhosphoSitePlus
K1097 Ubiquitination PhosphoSitePlus
T1130 Phosphorylation PhosphoSitePlus
K1133 Ubiquitination PhosphoSitePlus
K1165 Ubiquitination PhosphoSitePlus
K1217 Ubiquitination PhosphoSitePlus
K1253 Ubiquitination PhosphoSitePlus
Y1255 Phosphorylation PhosphoSitePlus
Y1259 Phosphorylation PhosphoSitePlus
K1265 Ubiquitination PhosphoSitePlus
K1271 Ubiquitination PhosphoSitePlus
K1278 Ubiquitination PhosphoSitePlus
K1289 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S601 Phosphorylation HPRD 18491316
T646 Phosphorylation HPRD 17081983, 20230923, 18767875, ...19664994, 19691289, 19651622, 18669648, 20068231
T648 Phosphorylation HPRD 19651622, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K66 N66 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S182 R182 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
T269 M269 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:3070 / malignant glioma [ cosmic ]
K304 N304 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S655 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S661 C661 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S664 C664 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K702 N702 Biomuta DOID:363 / uterine cancer [ tcga ]
K807 N807 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K1066 T1066 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K1165 E1165 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K1217 R1217 Biomuta DOID:3277 / thymus cancer [ tcga ]
K1253 N1253 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]