iPTMnet Report for O15409 (FOXP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15409 / FOXP2_HUMAN
Protein Name Forkhead box protein P2
Gene Name Name: FOXP2
Synonyms:CAGH44,TNRC10;
Organism Homo sapiens (Human)

PRO ID PR:O15409
DAG View
PRO Name forkhead box protein P2 (human)
Definition A forkhead box protein P2 that is encoded in the genome of human.
Short Label hFOXP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15409 (FOXP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation PhosphoSitePlus
S305 O-Glycosylation GlyGen 30620550, 35254053
S308 Phosphorylation PhosphoSitePlus
Y540 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus   RLIMS-P 29845391
K560 Ubiquitination PhosphoSitePlus
C561 Methylation IEDB 31844290
Y580 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S75 Phosphorylation HPRD 20068231
S591 Phosphorylation HPRD 20068231
T593 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S75 Phosphorylation HPRD 20068231
S616 Phosphorylation HPRD 20068231
T618 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S75 Y75 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S305 F305 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S557 G557 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S557 C557 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K560 R560 Biomuta DOID:3571 / liver cancer [ cosmic ]
C561 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S591 R591 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
T593 I593 Biomuta DOID:4159 / skin cancer [ cosmic ]
S616 R616 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
T618 I618 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]