iPTMnet Report for O15397 (IPO8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15397 / IPO8_HUMAN
Protein Name Importin-8
Gene Name Name: IPO8
Synonyms:RANBP8;
Organism Homo sapiens (Human)

PRO ID PR:O15397
DAG View
PRO Name importin-8 (human)
Definition An importin-8 that is encoded in the genome of human.
Short Label hIPO8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15397 (IPO8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
T13 Phosphorylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
Y30 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
K565 Acetylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
Y598 Phosphorylation PhosphoSitePlus
C736 Methylation IEDB 31844290
S842 Phosphorylation IEDB 30784271
S902 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 19690332
S903 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 19690332
T908 Phosphorylation PhosphoSitePlus
T1003 Phosphorylation PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S389 Phosphorylation HPRD 18691976
S902 Phosphorylation HPRD 18691976, 18669648, 18452278
S903 Phosphorylation HPRD 18691976, 18669648, 18452278
T908 Phosphorylation HPRD 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K403 N403 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
K503 R503 Biomuta DOID:363 / uterine cancer [ cosmic ]
K503 N503 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S595 C595 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y598 H598 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S902 A902 Biomuta DOID:363 / uterine cancer [ icgc ]
T1003 M1003 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T1003 S1003 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]