Protein Information

Cytoscape View

UniProt AC / UniProt ID O15371 / EIF3D_HUMAN
Protein Name Eukaryotic translation initiation factor 3 subunit D
Gene Name Name: EIF3D
Organism Homo sapiens (Human)

PRO ID PR:O15371
DAG View
PRO Name eukaryotic translation initiation factor 3 subunit D (human)
Definition A eukaryotic translation initiation factor 3 subunit D that is encoded in the genome of human.
Short Label hEIF3D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O15371 (EIF3D) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y30 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K41 Sumoylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
R95 Methylation PhosphoSitePlus
R97 Methylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus   UniProt 21406692
S166 Phosphorylation PhosphoSitePlus
K171 Sumoylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
R208 Methylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S308 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T317 Phosphorylation PhosphoSitePlus
Y318 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K412 Acetylation PhosphoSitePlus
K426 Methylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
Y520 Phosphorylation phospho.ELM 18669648
T526 Phosphorylation PhosphoSitePlus
S528 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18088087, 19690332
S529 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 17081983, 18669648, ...19690332, 20068231
T548 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation HPRD 17525332
T91 Phosphorylation HPRD 19664994, 20068231
S161 Phosphorylation HPRD 17081983
T230 Phosphorylation HPRD 20068231
S308 Phosphorylation HPRD 18669648
Y318 Phosphorylation HPRD 15592455
Y520 Phosphorylation HPRD 18669648
S521 Phosphorylation HPRD 17081983
T526 Phosphorylation HPRD 18691976, 17081983
S528 Phosphorylation HPRD 18691976, 18088087, 17081983, ...18452278, 19651622, 18669648, 19415658, 20068231
S529 Phosphorylation HPRD 18088087, 18452278, 19651622, ...18669648, 19415658, 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y30 * Biomuta DOID:3571 / liver cancer [ icgc ]
K35 N35 Biomuta DOID:1909 / melanoma [ cosmic ]
Y50 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y55 * Biomuta DOID:3571 / liver cancer [ icgc ]
R95 Q95 Biomuta DOID:1909 / melanoma [ cosmic ]
R97 Q97 Biomuta DOID:3963 / thyroid carcinoma [ icgc, tcga ]
R97 * Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
R208 S208 Biomuta DOID:3571 / liver cancer [ icgc ]
R208 H208 Biomuta DOID:1324 / lung cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
T526 I526 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]