iPTMnet Report for O15360 (FANCA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15360 / FANCA_HUMAN
Protein Name Fanconi anemia group A protein
Gene Name Name: FANCA
Synonyms:FAA,FACA,FANCH;
Organism Homo sapiens (Human)

PRO ID PR:O15360
DAG View
PRO Name Fanconi anemia group A protein (human)
Definition A Fanconi anemia group A protein that is encoded in the genome of human.
Short Label hFANCA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15360 (FANCA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K34 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus   RLIMS-P 27398318
C167 Methylation IEDB 31844290
K249 Ubiquitination PhosphoSitePlus
T256 Phosphorylation RLIMS-P 27398318
K261 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S347 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P+ 27449087
T351 Phosphorylation P51955 (NEK2) PhosphoSitePlus   RLIMS-P 23806870
S357 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
Y488 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
K612 Ubiquitination PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
R683 Methylation PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
S849 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
S858 Phosphorylation PhosphoSitePlus
K921 Sumoylation PhosphoSitePlus
Y929 Phosphorylation IEDB 35494241
K1079 Ubiquitination PhosphoSitePlus
S1149 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 11855836
K1199 Ubiquitination PhosphoSitePlus
S1208 Phosphorylation PhosphoSitePlus
S1301 Phosphorylation PhosphoSitePlus
T1309 Phosphorylation PhosphoSitePlus
K1387 Ubiquitination PhosphoSitePlus
K1398 Ubiquitination PhosphoSitePlus
C1410 Methylation IEDB 31844290
K1413 Ubiquitination PhosphoSitePlus
S1449 Phosphorylation Q13315 (ATM) , Q13535 (ATR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 17525332, 23186163, ...19109555
Site PTM Type PTM Enzyme Score Source PMID
S849 Phosphorylation HPRD 17924679
S850 Phosphorylation HPRD 17924679
S858 Phosphorylation HPRD 17924679
S1149 Phosphorylation P31749 (AKT1) HPRD 11855836
S1449 Phosphorylation HPRD 18691976, 17525332, 18077418
Site PTM Type PTM Enzyme Score Source PMID
K1399 Ubiquitination PhosphoSitePlus
K1414 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K34 Q34 Biomuta DOID:363 / uterine cancer [ icgc ]
K70 N70 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S165 F165 Biomuta DOID:4159 / skin cancer [ cosmic ]
T256 I256 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T256 A256 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T323 I323 Biomuta DOID:1319 / brain cancer [ cosmic ]
S337 F337 Biomuta DOID:4159 / skin cancer [ cosmic ]
S357 L357 Biomuta DOID:1324 / lung cancer [ cosmic ]
S421 N421 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K522 R522 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K522 N522 Biomuta DOID:363 / uterine cancer [ cosmic ]
K608 E608 Biomuta DOID:1324 / lung cancer [ cosmic ]
R683 I683 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K701 E701 Biomuta DOID:1324 / lung cancer [ cosmic ]
S858 R858 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ]
S1149 F1149 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1149 P1149 Biomuta DOID:1612 / breast cancer [ cosmic ]
K1199 N1199 Biomuta DOID:4362 / cervical cancer [ icgc ]