iPTMnet Report for O15357 (INPPL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15357 / SHIP2_HUMAN
Protein Name Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Gene Name Name: INPPL1
Synonyms:SHIP2;
Organism Homo sapiens (Human)

PRO ID PR:O15357
DAG View
PRO Name phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (human)
Definition A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 that is encoded in the genome of human.
Short Label hINPPL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15357 (INPPL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
Y62 Phosphorylation PhosphoSitePlus
S132 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21770892, 23186163, 17081983
S158 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T165 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T167 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S182 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
R198 Methylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S241 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K272 Acetylation PhosphoSitePlus
S276 O-Glycosylation GlyGen 23301498, 30379171, 35132862, ...29351928
K284 Ubiquitination PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus   UniProt 23186163
K376 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
Y622 Phosphorylation PhosphoSitePlus
Y661 Phosphorylation PhosphoSitePlus
Y663 Phosphorylation PhosphoSitePlus
Y671 Phosphorylation phospho.ELM   PhosphoSitePlus 12522270
C689 Methylation IEDB 31844290
K741 Ubiquitination PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
S827 Phosphorylation IEDB   PhosphoSitePlus 32387766
Y831 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
T854 Phosphorylation PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus
T881 Phosphorylation PhosphoSitePlus
Y886 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 23186163, 12522270
S890 Phosphorylation PhosphoSitePlus   UniProt 23186163
C926 S-Nitrosylation dbSNO 26338901
T958 Phosphorylation PhosphoSitePlus   UniProt 17219406, 23186163
S980 Phosphorylation PhosphoSitePlus
Y986 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12235291, 17081983, 18083107, ...18669648, 11349134, 15592455, 12522270
Y986 Phosphorylation P12931 (SRC) phospho.ELM   Signor 12235291
Y987 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12235291
Y987 Phosphorylation P12931 (SRC) phospho.ELM   Signor 12235291
S1003 Phosphorylation phospho.ELM   PhosphoSitePlus 15951569, 17081983
S1011 Phosphorylation PhosphoSitePlus
T1013 Phosphorylation PhosphoSitePlus
T1047 Phosphorylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
R1080 Methylation PhosphoSitePlus
R1086 Methylation PhosphoSitePlus
R1096 Methylation PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
T1129 Phosphorylation PhosphoSitePlus
S1131 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1135 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 22194892, ...24561238, 12522270
R1142 Methylation PhosphoSitePlus
S1160 Phosphorylation PhosphoSitePlus
Y1162 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12522270, 23186163, 11687594
S1167 Phosphorylation PhosphoSitePlus
S1176 Phosphorylation PhosphoSitePlus
S1202 Phosphorylation PhosphoSitePlus
Y1213 Phosphorylation PhosphoSitePlus
T1253 Phosphorylation PhosphoSitePlus
S1257 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S132 Phosphorylation HPRD 19651622, 18452278
S158 Phosphorylation HPRD 18669648
T165 Phosphorylation HPRD 18669648
T167 Phosphorylation HPRD 18669648
S240 Phosphorylation HPRD 18691976
S241 Phosphorylation HPRD 18691976, 18669648, 20068231
S290 Phosphorylation HPRD 20068231
S291 Phosphorylation HPRD 20068231
Y671 Phosphorylation HPRD 12522270
Y886 Phosphorylation HPRD 19901323, 12522270, 17389395, ...20068231
S890 Phosphorylation HPRD 20068231
Y986 Phosphorylation HPRD 19901323, 18669648, 17389395, ...12235291, 16497976
Y986 Phosphorylation P12931 (SRC) HPRD 19901323, 18669648, 17389395, ...12235291, 16497976
Y987 Phosphorylation HPRD 12235291, 16497976
Y987 Phosphorylation P12931 (SRC) HPRD 12235291, 16497976
S1003 Phosphorylation HPRD 19901323, 12522270
S1038 Phosphorylation HPRD 20068231
S1039 Phosphorylation HPRD 20068231
S1061 Phosphorylation HPRD 20068231
S1068 Phosphorylation HPRD 20068231
Y1135 Phosphorylation HPRD 19901323, 12522270, 17389395, ...16497976
Y1162 Phosphorylation HPRD 12522270, 16497976


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P08581 (MET) Y1356 O15357 (INPPL1) unknown eFIP 30165040
Phosphorylation Q9UQB8 (BAIAP2) S366 O15357 (INPPL1) unknown eFIP 32535200


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S158 T158 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R198 M198 Biomuta DOID:1324 / lung cancer [ cosmic ]
S240 I240 Biomuta DOID:3571 / liver cancer [ cosmic ]
S241 L241 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K272 N272 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S276 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S291 C291 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y661 F661 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y663 C663 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K779 R779 Biomuta DOID:4159 / skin cancer [ cosmic ]
S857 F857 Biomuta DOID:4159 / skin cancer [ cosmic ]
T958 A958 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1003 L1003 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1011 F1011 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1011 P1011 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1013 I1013 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1068 N1068 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R1080 H1080 Biomuta DOID:3571 / liver cancer [ cosmic ]
R1086 C1086 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T1129 M1129 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1142 C1142 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1160 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1162 H1162 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1176 N1176 Biomuta DOID:10534 / stomach cancer [ cosmic ]