iPTMnet Report for O15344 (MID1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15344 / TRI18_HUMAN
Protein Name E3 ubiquitin-protein ligase Midline-1
Gene Name Name: MID1
Synonyms:FXY,RNF59,TRIM18,XPRF;
Organism Homo sapiens (Human)

PRO ID PR:O15344
DAG View
PRO Name E3 ubiquitin-protein ligase Midline-1 (human)
Definition An E3 ubiquitin-protein ligase Midline-1 that is encoded in the genome of human.
Short Label hMID1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15344 (MID1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation PhosphoSitePlus
R68 Methylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
T78 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
S92 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...18669648, 11806752
S96 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 11806752, 18949047, ...18669648
S98 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T110 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus   UniProt 23186163
S513 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S90 Phosphorylation HPRD 20068231
S92 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
S96 Phosphorylation HPRD 19413330, 11371618, 18669648, ...20068231, 19664995
S98 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S66 N66 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R68 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R68 Q68 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K74 R74 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K232 Q232 Biomuta DOID:363 / uterine cancer [ icgc ]
Y378 C378 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S500 P500 Biomuta DOID:4606 / bile duct cancer [ cosmic ]