iPTMnet Report for O15297 (PPM1D)
Protein Information
| UniProt AC / UniProt ID | O15297 / PPM1D_HUMAN |
| Protein Name | Protein phosphatase 1D |
| Gene Name | Name: PPM1D Synonyms:WIP1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O15297 |
| PRO Name | protein phosphatase 1D (human) |
| Definition | A protein phosphatase 1D that is encoded in the genome of human. |
| Short Label | hPPM1D |
| Category | organism-gene |
O15297 (PPM1D) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K19 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S40 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
| S46 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S54 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S85 | Phosphorylation | Q9H2X6 (HIPK2) | score4 | PhosphoSitePlus UniProt | 23871434, 23186163 | |
| S89 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S97 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K162 | Acetylation | score1 | PhosphoSitePlus | |||
| K184 | Acetylation | score1 | PhosphoSitePlus | |||
| K218 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S234 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K238 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S239 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y308 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S432 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K469 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T517 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T529 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K535 | Methylation | score1 | PhosphoSitePlus | |||
| T537 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
| S541 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S543 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S565 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S570 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K589 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S46 | P46 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| S54 | * | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| S54 | L54 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| K218 | E218 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| S239 | Y239 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y308 | F308 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| Y308 | C308 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K469 | * | Biomuta | DOID:3119 / gastrointestinal system cancer [ cosmic ] | |
| K535 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| T537 | A537 | Biomuta | DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| S570 | P570 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
DAG View