Protein Information

Cytoscape View


UniProt AC / UniProt ID O15297 / PPM1D_HUMAN
Protein Name Protein phosphatase 1D
Gene Name Name: PPM1D
Synonyms:WIP1;
Organism Homo sapiens (Human)

PRO ID PR:O15297
DAG View
PRO Name protein phosphatase 1D (human)
Definition A protein phosphatase 1D that is encoded in the genome of human.
Short Label hPPM1D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15297 (PPM1D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus   UniProt 19690332
S46 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
S85 Phosphorylation Q9H2X6 (HIPK2) PhosphoSitePlus   UniProt 23871434, 23186163
S89 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
K184 Acetylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
Y308 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus
T529 Phosphorylation PhosphoSitePlus
K535 Methylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S85 Phosphorylation HPRD 19007248


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K218 E218 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y308 F308 Biomuta DOID:1324 / lung cancer [ cosmic ]