iPTMnet Report for O15270 (SPTLC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15270 / SPTC2_HUMAN
Protein Name Serine palmitoyltransferase 2
Gene Name Name: SPTLC2
Synonyms:KIAA0526,LCB2;
Organism Homo sapiens (Human)

PRO ID PR:O15270
DAG View
PRO Name serine palmitoyltransferase 2 (human)
Definition A serine palmitoyltransferase 2 that is encoded in the genome of human.
Short Label hSPTLC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15270 (SPTLC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C139 Methylation IEDB 31844290
K161 Ubiquitination PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
C204 Methylation IEDB 31844290
K215 Ubiquitination PhosphoSitePlus
K281 Methylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
S384 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 25567748, 17081983
Y387 Phosphorylation HPRD   phospho.ELM   RLIMS-P 25567748, 17081983
K391 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
T409 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
T501 Phosphorylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
R550 Methylation PhosphoSitePlus
T555 Phosphorylation PhosphoSitePlus
Y557 Phosphorylation PhosphoSitePlus
T560 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y178 C178 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K194 R194 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K215 N215 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K281 E281 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K392 R392 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T432 A432 Biomuta DOID:4159 / skin cancer [ cosmic ]
S433 R433 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T555 M555 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T560 K560 Biomuta DOID:3571 / liver cancer [ cosmic ]