iPTMnet Report O15269 SPTLC1

Protein Information

UniProt AC / UniProt ID	O15269 / SPTC1_HUMAN
Protein Name	Serine palmitoyltransferase 1
Gene Name	Name: SPTLC1 Synonyms:LCB1;
Organism	Homo sapiens (Human)

PRO ID	PR:O15269 DAG View
PRO Name	serine palmitoyltransferase 1 (human)
Definition	A serine palmitoyltransferase 1 that is encoded in the genome of human.
Short Label	hSPTLC1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O15269 (SPTLC1) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K45 S50 T53 K55 K57 K75 Y82 K92 K118 K126 K127 Y164 C192 K197 K207 K210 K222 K230 K369 K375 K384 S389 S391 K434 C438 S443 T453 K465	PTM Type Select all Acetylation Methylation Phosphorylation S-Nitrosylation Ubiquitination	PTM Enzyme	Score Select all 0 1 3	Source Select all IEDB PhosphoSitePlus RLIMS-P Signor UniProt dbSNO	PMID
K45	Ubiquitination		score1	PhosphoSitePlus
S50	Phosphorylation		score1	PhosphoSitePlus
T53	Phosphorylation		score1	PhosphoSitePlus
K55	Ubiquitination		score1	PhosphoSitePlus
K57	Ubiquitination		score1	PhosphoSitePlus
K75	Ubiquitination		score1	PhosphoSitePlus
Y82	Phosphorylation		score1	PhosphoSitePlus
K92	Ubiquitination		score1	PhosphoSitePlus
K118	Ubiquitination		score1	PhosphoSitePlus
K126	Ubiquitination		score1	PhosphoSitePlus
K127	Ubiquitination		score1	PhosphoSitePlus
Y164	Phosphorylation	P00519 (ABL1)	score3	PhosphoSitePlus RLIMS-P Signor UniProt	23629659
C192	Methylation		score1	IEDB	31844290
K197	Ubiquitination		score1	PhosphoSitePlus
K207	Ubiquitination		score1	PhosphoSitePlus
K210	Methylation		score1	PhosphoSitePlus
K210	Ubiquitination		score1	PhosphoSitePlus
K222	Ubiquitination		score1	PhosphoSitePlus
K230	Ubiquitination		score1	PhosphoSitePlus
K369	Ubiquitination		score1	PhosphoSitePlus
K375	Ubiquitination		score1	PhosphoSitePlus
K384	Ubiquitination		score1	PhosphoSitePlus
S389	Phosphorylation		score1	PhosphoSitePlus
S391	Phosphorylation		score1	PhosphoSitePlus
K434	Acetylation		score1	PhosphoSitePlus
K434	Ubiquitination		score1	PhosphoSitePlus
C438	S-Nitrosylation		score0	dbSNO	26338901
S443	Phosphorylation		score1	PhosphoSitePlus
T453	Phosphorylation		score1	PhosphoSitePlus
K465	Ubiquitination		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Serine By position S443	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0	Source Select all HPRD	PMID
	S443	Phosphorylation		score0	HPRD	18491316

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position K118 K222 K230 K369 S443 T453	Variant Select all E118 I443 I453 N222 N230 N369	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K118	E118	Biomuta	DOID:263 / kidney cancer [ cosmic ]
K222	N222	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
K230	N230	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
K369	N369	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S443	I443	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T453	I453	Biomuta	DOID:5041 / esophageal cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O15269 (SPTLC1)

Protein Information

Interactive Sequence View

O15269 (SPTLC1) as Substrate

PTM sites affected in variants