iPTMnet Report for O15269 (SPTLC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15269 / SPTC1_HUMAN
Protein Name Serine palmitoyltransferase 1
Gene Name Name: SPTLC1
Synonyms:LCB1;
Organism Homo sapiens (Human)

PRO ID PR:O15269
DAG View
PRO Name serine palmitoyltransferase 1 (human)
Definition A serine palmitoyltransferase 1 that is encoded in the genome of human.
Short Label hSPTLC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15269 (SPTLC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K45 Ubiquitination PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
T53 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
Y164 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 23629659
C192 Methylation IEDB 31844290
K197 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K210 Methylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
K434 Acetylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
C438 S-Nitrosylation dbSNO 26338901
S443 Phosphorylation PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S443 Phosphorylation HPRD 18491316


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K118 E118 Biomuta DOID:263 / kidney cancer [ cosmic ]
K222 N222 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K230 N230 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K369 N369 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S443 I443 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T453 I453 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]