iPTMnet Report for O15264 (MAPK13)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15264 / MK13_HUMAN
Protein Name Mitogen-activated protein kinase 13
Gene Name Name: MAPK13
Synonyms:PRKM13,SAPK4;
Organism Homo sapiens (Human)

PRO ID PR:O15264
DAG View
PRO Name mitogen-activated protein kinase 13 (human)
Definition A mitogen-activated protein kinase 13 that is encoded in the genome of human.
Short Label hMAPK13
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15264 (MAPK13) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S47 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087
S143 Phosphorylation PhosphoSitePlus
T180 Phosphorylation P52564 (MAP2K6) , P46734 (MAP2K3) neXtProt   PRO   PhosphoSitePlus   UniProt 8846784, 9374491, 9790884
Y182 Phosphorylation P52564 (MAP2K6) , P46734 (MAP2K3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 18083107, 8846784, 9374491, ...9790884
T185 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus   UniProt 19369195
S357 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation HPRD 18088087
T180 Phosphorylation P52564 (MAP2K6) HPRD 9218798
Y182 Phosphorylation HPRD 9218798


O15264 (MAPK13) as PTM Enzyme



Substrate Site Score Source PMID
O00418 (EEF2K) S359 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12171600, 18337751, 11500363
O00418 (EEF2K) S396 HPRD   neXtProt   PhosphoSitePlus 12171600, 11500363
P04637 (TP53) S33 Signor 10581258
P04637 (TP53) S46 Signor 10581258
P05787 (KRT8) S74 Signor 11788583
P10636-8 (MAPT) T50 neXtProt 15632108
P10636-8 (MAPT) T69 neXtProt 15632108
P10636-8 (MAPT) T153 neXtProt 15632108
P10636-8 (MAPT) S202 neXtProt 15632108
P10636-8 (MAPT) T205 neXtProt 15632108
P10636-8 (MAPT) T212 neXtProt   PhosphoSitePlus 16987243
P10636-8 (MAPT) T217 neXtProt   PhosphoSitePlus 16987243
P10636-8 (MAPT) S235 neXtProt 15632108
P10636-8 (MAPT) S396 neXtProt   PhosphoSitePlus 10620503
P10636-8 (MAPT) S404 neXtProt   PhosphoSitePlus 10620503, 15632108
P10636-8 (MAPT) S422 neXtProt 15632108
P16949 (STMN1) S25 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16110469, 8125092, 9731215, ...8325880
P16949 (STMN1) S38 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16110469, 9731215, 8325880
P30281 (CCND3) T283 neXtProt   PhosphoSitePlus 15326477
P78352 (DLG4) T287 neXtProt 14741046
Q13501 (SQSTM1) T269 PhosphoSitePlus 26279575
Q13501 (SQSTM1) S272 PhosphoSitePlus 26279575
Q14934 (NFATC4) S168 neXtProt 11997522
Q14934 (NFATC4) S170 neXtProt 11997522
Q15139 (PRKD1) S208 neXtProt 19135240
Q15139 (PRKD1) S249 neXtProt 19135240
Q15139 (PRKD1) S397 neXtProt 19135240
Q15139 (PRKD1) S401 neXtProt 19135240
Q15139 (PRKD1) S742 neXtProt 19135240
Q8IW41 (MAPKAPK5) T182 neXtProt 9628874
Q8NHW3 (MAFA) T57 neXtProt 15963504
Q8NHW3 (MAFA) T134 neXtProt 15963504
Q8NHW3 (MAFA) S336 neXtProt 15963504


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048318 (hMAPK13/Phos:1) pT180,pY182 PRO 8846784


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y10 C10 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S261 F261 Biomuta DOID:4159 / skin cancer [ cosmic ]
T265 I265 Biomuta DOID:9256 / colorectal cancer [ cosmic ]