Protein Information

Cytoscape View


UniProt AC / UniProt ID O15234 / CASC3_HUMAN
Protein Name Protein CASC3
Gene Name Name: CASC3
Synonyms:MLN51;
Organism Homo sapiens (Human)

PRO ID PR:O15234
DAG View
PRO Name protein CASC3 (human)
Definition A protein CASC3 that is encoded in the genome of human.
Short Label hCASC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15234 (CASC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation HPRD   PhosphoSitePlus 18452278
S35 Phosphorylation PhosphoSitePlus
S37 Phosphorylation HPRD   PhosphoSitePlus 19413330
S39 Phosphorylation PhosphoSitePlus
S45 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19664995
S47 Phosphorylation PhosphoSitePlus
R52 Methylation PhosphoSitePlus
R55 Methylation PhosphoSitePlus
S66 Phosphorylation HPRD   PhosphoSitePlus 20068231
S117 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 24275569
S125 Phosphorylation HPRD   PhosphoSitePlus 19651622
K128 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
T141 Phosphorylation HPRD   PhosphoSitePlus 19664995
T143 Phosphorylation HPRD   PhosphoSitePlus 19651622
S148 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...19369195, 19664995, 19651622, 18669648, 24275569
S154 Phosphorylation PhosphoSitePlus
T155 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
R194 Methylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
Y263 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S265 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 18767875, ...19651622, 20068231
T304 Phosphorylation PhosphoSitePlus
R306 Methylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
R323 Methylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus   UniProt 24275569
S358 Phosphorylation PhosphoSitePlus
S363 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19664994, 19651622, 18669648, 20068231
S373 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 19651622, ...18669648, 20068231
S381 Phosphorylation PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
S477 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
R490 Methylation PhosphoSitePlus
R518 Methylation PhosphoSitePlus
T684 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S45 T45 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R55 Q55 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K177 N177 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R194 * Biomuta DOID:1909 / melanoma [ tcga ]
Y263 F263 Biomuta DOID:1324 / lung cancer [ tcga ]
R306 H306 Biomuta DOID:5041 / esophageal cancer [ icgc ]
R323 P323 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
R323 C323 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R323 H323 Biomuta DOID:363 / uterine cancer [ tcga ]
K344 * Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T357 A357 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R490 Q490 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R518 * Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]