iPTMnet Report for O15226 (NKRF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15226 / NKRF_HUMAN
Protein Name NF-kappa-B-repressing factor
Gene Name Name: NKRF
Synonyms:ITBA4,NRF;
Organism Homo sapiens (Human)

PRO ID PR:O15226
DAG View
PRO Name NF-kappa-B-repressing factor (human)
Definition An NF-kappa-B-repressing factor that is encoded in the genome of human.
Short Label hNKRF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15226 (NKRF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation PhosphoSitePlus
Y19 Phosphorylation PhosphoSitePlus
K25 Sumoylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K68 Sumoylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
K81 Sumoylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
Y216 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
Y255 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K288 Methylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
Y368 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K407 Sumoylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
S422 Phosphorylation HPRD 17081983
S429 Phosphorylation PhosphoSitePlus
K440 Sumoylation PhosphoSitePlus
S486 Phosphorylation HPRD   PhosphoSitePlus 20068231
K500 Sumoylation PhosphoSitePlus
Y501 Phosphorylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus
K523 Sumoylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
K524 Sumoylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K546 Methylation PhosphoSitePlus
K546 Sumoylation PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
K550 Sumoylation PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K561 Sumoylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
T565 Phosphorylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
K583 Sumoylation PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus   UniProt 23186163
T620 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
K648 Acetylation PhosphoSitePlus
R656 Methylation PhosphoSitePlus
K666 Methylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K674 Sumoylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
Y682 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K68 N68 Biomuta DOID:263 / kidney cancer [ cosmic ]
K222 Q222 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K234 Q234 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K276 E276 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K407 N407 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K420 N420 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y501 C501 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K513 T513 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K523 R523 Biomuta DOID:4159 / skin cancer [ cosmic ]
S572 Y572 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S572 F572 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S616 F616 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S618 R618 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T620 I620 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K642 N642 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R656 M656 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R656 G656 Biomuta DOID:9256 / colorectal cancer [ cosmic ]