iPTMnet Report for O15198 (SMAD9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15198 / SMAD9_HUMAN
Protein Name Mothers against decapentaplegic homolog 9
Gene Name Name: SMAD9
Synonyms:MADH6,MADH9,SMAD8;
Organism Homo sapiens (Human)

PRO ID PR:O15198
DAG View
PRO Name mothers against decapentaplegic homolog 9 (human)
Definition A smad9 that is encoded in the genome of human.
Short Label hSMAD9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15198 (SMAD9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K25 Ubiquitination PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
R57 Methylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus 22394512
T136 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 22394512
K159 Ubiquitination PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
C412 Methylation IEDB 31844290
K420 Ubiquitination PhosphoSitePlus
C436 Methylation IEDB 31844290
S458 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S465 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 18669648, 17081983
S467 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 18669648, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S465 Phosphorylation PRO
S467 Phosphorylation PRO
Site PTM Type PTM Enzyme Score Source PMID
S427 Phosphorylation HPRD 20068231
S428 Phosphorylation HPRD 18767875, 18669648, 17081983, ...20068231
S430 Phosphorylation HPRD 18669648, 17081983, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049291 (hSMAD9/Phos:1) pS465,pS467 PRO
PR:000028350 (hSMAD9/iso:3/Phos:1) pS465,pS467 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y92 C92 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K159 R159 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]