Protein Information

Cytoscape View


UniProt AC / UniProt ID O15173 / PGRC2_HUMAN
Protein Name Membrane-associated progesterone receptor component 2
Gene Name Name: PGRMC2
Synonyms:DG6,PMBP;
Organism Homo sapiens (Human)

PRO ID PR:O15173
DAG View
PRO Name membrane-associated progesterone receptor component 2 (human)
Definition A membrane-associated progesterone receptor component 2 that is encoded in the genome of human.
Short Label hPGRMC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15173 (PGRMC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S90 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...19369195, 24275569, 19690332, 20068231
T93 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus   UniProt 23186163
R109 Methylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
R149 Methylation PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
R166 Methylation PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S208 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
Y210 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T211 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
T216 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R166 T166 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S173 * Biomuta DOID:5041 / esophageal cancer [ tcga ]