iPTMnet Report for O15160 (POLR1C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15160 / RPAC1_HUMAN
Protein Name DNA-directed RNA polymerases I and III subunit RPAC1
Gene Name Name: POLR1C
Synonyms:POLR1E;
Organism Homo sapiens (Human)

PRO ID PR:O15160
DAG View
PRO Name DNA-directed RNA polymerases I and III subunit RPAC1 (human)
Definition A DNA-directed RNA polymerases I and III subunit RPAC1 that is encoded in the genome of human.
Short Label hPOLR1C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15160 (POLR1C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y33 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
S34 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
R120 Methylation PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
R125 Methylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
C256 S-Nitrosylation dbSNO 26338901
S258 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y33 Phosphorylation HPRD 15592455
S226 Phosphorylation HPRD 20068231
S254 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R120 H120 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R120 C120 Biomuta DOID:1324 / lung cancer [ cosmic ]
K154 E154 Biomuta DOID:1324 / lung cancer [ cosmic ]
K224 T224 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C256 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K332 Q332 Biomuta DOID:263 / kidney cancer [ cosmic ]