iPTMnet Report for O15151 (MDM4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15151 / MDM4_HUMAN
Protein Name Protein Mdm4
Gene Name Name: MDM4
Synonyms:MDMX;
Organism Homo sapiens (Human)

PRO ID PR:O15151
DAG View
PRO Name protein Mdm4 (human)
Definition A protein Mdm4 that is encoded in the genome of human.
Short Label hMDM4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15151 (MDM4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S20 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus 19075013
Y55 Phosphorylation P00519 (ABL1) PhosphoSitePlus 19075013
K93 Ubiquitination PhosphoSitePlus
S96 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 15735705
S96 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   Signor 15735705
Y99 Phosphorylation PhosphoSitePlus   RLIMS-P 19075013, 26148237
Y99 Phosphorylation P00519 (ABL1) PhosphoSitePlus 19075013
T119 Phosphorylation IEDB   PhosphoSitePlus 35494241
S161 Phosphorylation PhosphoSitePlus
K254 Sumoylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S289 Phosphorylation neXtProt   PhosphoSitePlus   Signor 23028042, 16024788
S289 Phosphorylation P48729 (CSNK1A1) neXtProt   PhosphoSitePlus   Signor 23028042, 16024788
S314 Phosphorylation PhosphoSitePlus   RLIMS-P 27777309
K336 Ubiquitination PhosphoSitePlus
S342 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 19808970, 24190973, 23186163, ...16943424, 16163388
S342 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   Signor 16163388
S342 Phosphorylation O96017 (CHEK2) PhosphoSitePlus   Signor 16943424, 16163388
S342 Phosphorylation P54646 (PRKAA2) RLIMS-P+ 24190973
S342 Phosphorylation Q13315 (ATM) Signor 16943424
T365 Phosphorylation PhosphoSitePlus
S367 Phosphorylation IntAct   neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19808970, 23186163, 16943424, ...16511560, 18356162, 16227609, 16511572, 22120712, 16163388
S367 Phosphorylation O14757 (CHEK1) neXtProt   PhosphoSitePlus   Signor 18356162, 16163388, 16511572
S367 Phosphorylation O96017 (CHEK2) PhosphoSitePlus   Signor 16943424, 18356162, 16163388, ...16511560
S367 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 18356162
S367 Phosphorylation Q13315 (ATM) Signor 16943424
K374 Ubiquitination PhosphoSitePlus
K379 Sumoylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
C389 Methylation IEDB 31844290
S403 Phosphorylation neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor 15788536, 16163388, 16943424
S403 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   Signor 15788536, 16943424
Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO 16511560
S161 Phosphorylation HPRD 16163388
S342 Phosphorylation HPRD 16163388, 16511560
S342 Phosphorylation O14757 (CHEK1) HPRD 16163388
S342 Phosphorylation O96017 (CHEK2) HPRD 16163388
S342 Phosphorylation P31749 (AKT1) HPRD 16163388, 16511560
T365 Phosphorylation HPRD 15788536
S367 Phosphorylation HPRD   PRO 17110929, 16163388, 16511572, ...16511560
S367 Phosphorylation O14757 (CHEK1) HPRD 17110929, 16163388
S367 Phosphorylation O96017 (CHEK2) HPRD 16163388, 16511560
S391 Phosphorylation HPRD 16163388, 16511560
S403 Phosphorylation HPRD 15788536, 16163388, 16511560
S403 Phosphorylation Q13315 (ATM) HPRD 15788536, 16163388, 16511560


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048361 (hMDM4/Phos:2) pS342,pS367,pS403 PRO
PR:000048362 (hMDM4/Phos:3) pS403 PRO
PR:000048363 (hMDM4/UbiqLys+) ub PRO
PR:000025837 (hMDM4/iso:1/PhosUbiq:1) ub PRO 16511560
PR:000025837 (hMDM4/iso:1/PhosUbiq:1) pS367 PRO 16511560


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O15151 (MDM4) Y99 P04637 (TP53) decreased_association eFIP 32850448
Phosphorylation O15151 (MDM4) Y99 P04637 (TP53) inhibited_association eFIP 20651945
Phosphorylation P04637 (TP53) S20 O15151 (MDM4) decreased_association eFIP 20174603


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025837 (hMDM4/iso:1/PhosUbiq:1) Interaction PR:P27348 (hYWHAQ) PRO 16511560
PR:000025837 (hMDM4/iso:1/PhosUbiq:1) Interaction PR:P61981 (hYWHAG) PRO 16511572