iPTMnet Report for O15143 (ARPC1B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15143 / ARC1B_HUMAN
Protein Name Actin-related protein 2/3 complex subunit 1B
Gene Name Name: ARPC1B
Synonyms:ARC41;
Organism Homo sapiens (Human)

PRO ID PR:O15143
DAG View
PRO Name actin-related protein 2/3 complex subunit 1B (human)
Definition An actin-related protein 2/3 complex subunit 1B that is encoded in the genome of human.
Short Label hARPC1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15143 (ARPC1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K18 Acetylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
T21 Phosphorylation O14965 (AURKA) , Q13153 (PAK1) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 14749719, 20603326
C26 Methylation IEDB 31844290
Y35 Phosphorylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
K44 Acetylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
Y77 Phosphorylation PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
T89 Phosphorylation HPRD   PhosphoSitePlus 20068231
K110 Ubiquitination PhosphoSitePlus
C123 Methylation IEDB 31844290
K138 Ubiquitination PhosphoSitePlus
S170 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
Y172 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
K174 Acetylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
C202 Methylation IEDB 31844290
C227 Methylation IEDB 31844290
C265 Methylation IEDB 31844290
K289 Ubiquitination PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
S310 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 17081983, 20068231
S311 Phosphorylation HPRD   PhosphoSitePlus 18707149
T315 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S323 Phosphorylation PhosphoSitePlus
K326 Methylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
S328 Phosphorylation HPRD   PhosphoSitePlus 20068231
S330 Phosphorylation HPRD 20068231
S336 Phosphorylation HPRD   PhosphoSitePlus 20068231
K339 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O15143 (ARPC1B) T21 O14965 (AURKA) unknown eFIP 20603326


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K37 N37 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K41 E41 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K44 N44 Biomuta DOID:363 / uterine cancer [ icgc ]
T89 M89 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S311 F311 Biomuta DOID:9256 / colorectal cancer [ cosmic ]