Protein Information

Cytoscape View

UniProt AC / UniProt ID O15121 / DEGS1_HUMAN
Protein Name Sphingolipid delta(4)-desaturase DES1
Gene Name Name: DEGS1
Organism Homo sapiens (Human)

PRO ID PR:O15121
DAG View
PRO Name sphingolipid Delta(4)-desaturase DES1 (human)
Definition A sphingolipid Delta(4)-desaturase DES1 that is encoded in the genome of human.
Short Label hDEGS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O15121 (DEGS1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 19647031, 25255805
Y14 Phosphorylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
S307 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
K317 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K29 N29 Biomuta DOID:363 / uterine cancer [ tcga ]
K29 R29 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]