iPTMnet Report O15119 TBX3

Protein Information

UniProt AC / UniProt ID	O15119 / TBX3_HUMAN
Protein Name	T-box transcription factor TBX3
Gene Name	Name: TBX3
Organism	Homo sapiens (Human)

PRO ID	PR:O15119 DAG View
PRO Name	T-box transcription factor TBX3 (human)
Definition	A T-box transcription factor TBX3 that is encoded in the genome of human.
Short Label	hTBX3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O15119 (TBX3) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
K104	Ubiquitination		score1	PhosphoSitePlus
K110	Ubiquitination		score1	PhosphoSitePlus
K118	Ubiquitination		score1	PhosphoSitePlus
T121	Phosphorylation		score1	PhosphoSitePlus
K127	Ubiquitination		score1	PhosphoSitePlus
Y163	Phosphorylation		score1	PhosphoSitePlus
Y185	Phosphorylation		score1	PhosphoSitePlus
S190	Phosphorylation		score0	RLIMS-P	27110270
T203	Phosphorylation		score1	PhosphoSitePlus
K206	Ubiquitination		score1	PhosphoSitePlus
K208	Ubiquitination		score1	PhosphoSitePlus
Y265	Phosphorylation		score1	PhosphoSitePlus
K293	Ubiquitination		score1	PhosphoSitePlus
K301	Ubiquitination		score1	PhosphoSitePlus
K313	Ubiquitination		score1	PhosphoSitePlus
S371	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
S375	Phosphorylation		score1	PhosphoSitePlus
S381	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S396	Phosphorylation		score1	PhosphoSitePlus
S400	Phosphorylation		score1	PhosphoSitePlus
S409	Phosphorylation		score1	PhosphoSitePlus
K413	Ubiquitination		score1	PhosphoSitePlus
S432	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18220336
S435	Phosphorylation		score1	PhosphoSitePlus
S438	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	23186163, 24275569, 18220336
T441	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18220336
S443	Phosphorylation		score1	PhosphoSitePlus
S444	Phosphorylation		score1	PhosphoSitePlus
S445	Phosphorylation		score1	PhosphoSitePlus
T446	Phosphorylation		score1	PhosphoSitePlus
S456	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
T462	Phosphorylation		score1	PhosphoSitePlus
K466	Ubiquitination		score1	PhosphoSitePlus
S680	Phosphorylation		score1	PhosphoSitePlus
S696	O-Glycosylation		score1	GlyGen	30379171
S697	O-Glycosylation		score1	GlyGen	30379171
S707	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
K714	Ubiquitination		score1	PhosphoSitePlus
T718	Phosphorylation		score1	PhosphoSitePlus
S719	Phosphorylation	Q9Y243 (AKT3)	score3	PhosphoSitePlus Signor	25595898
S729	Phosphorylation		score1	PhosphoSitePlus
K734	Ubiquitination		score1	PhosphoSitePlus
S738	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S740	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
S742	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648

Site	PTM Type	Score	Source	PMID
S371	Phosphorylation	score0	HPRD	19413330, 18669648
S375	Phosphorylation	score0	HPRD	19413330
S381	Phosphorylation	score0	HPRD	18669648
S456	Phosphorylation	score0	HPRD	18767875, 17081983
S707	Phosphorylation	score0	HPRD	17322306, 18669648, 19664994
S738	Phosphorylation	score0	HPRD	18669648
S740	Phosphorylation	score0	HPRD	18669648
S742	Phosphorylation	score0	HPRD	18669648

Site	PTM Type	Score	Source	PMID
S351	Phosphorylation	score0	HPRD	19413330, 18669648
S355	Phosphorylation	score0	HPRD	19413330
S361	Phosphorylation	score0	HPRD	18669648
S436	Phosphorylation	score0	HPRD	18767875, 17081983
S687	Phosphorylation	score0	HPRD	17322306, 18669648, 19664994
S718	Phosphorylation	score0	HPRD	18669648
S720	Phosphorylation	score0	HPRD	18669648
S722	Phosphorylation	score0	HPRD	18669648

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
K118	R118	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T121	A121	Biomuta	DOID:1612 / breast cancer [ cosmic ]
Y163	C163	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
Y185	D185	Biomuta	[ cosmic ]
T203	N203	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y265	H265	Biomuta	DOID:4159 / skin cancer [ cosmic ]
Y265	C265	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S351	C351	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S355	N355	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S371	C371	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S375	N375	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S396	F396	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S396	C396	Biomuta	DOID:263 / kidney cancer [ cosmic ]
S396	T396	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S396	P396	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S400	L400	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S432	L432	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S435	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S438	R438	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S443	L443	Biomuta	DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S680	R680	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S719	G719	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S729	R729	Biomuta	DOID:3571 / liver cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O15119 (TBX3)

Protein Information

Interactive Sequence View

O15119 (TBX3) as Substrate

PTM sites affected in variants