iPTMnet Report for O15105 (SMAD7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15105 / SMAD7_HUMAN
Protein Name Mothers against decapentaplegic homolog 7
Gene Name Name: SMAD7
Synonyms:MADH7,MADH8;
Organism Homo sapiens (Human)

PRO ID PR:O15105
DAG View
PRO Name mothers against decapentaplegic homolog 7 (human)
Definition A smad7 that is encoded in the genome of human.
Short Label hSMAD7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15105 (SMAD7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R57 Methylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus   UniProt 12408818
K64 Ubiquitination UniProt 12408818
R67 Methylation PhosphoSitePlus
K70 Acetylation UniProt 12408818
K70 Methylation PhosphoSitePlus
K70 Ubiquitination UniProt 12408818
T96 Phosphorylation Q14680 (MELK) neXtProt   PhosphoSitePlus 20659902
K101 Ubiquitination PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus   RLIMS-P 31546607
S249 Phosphorylation RLIMS-P 11278814
T354 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K64 Acetylation PRO 12408818
K70 Acetylation PRO 12408818
S249 Phosphorylation PRO


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036565 (hSMAD7/iso:1/Ac:1) acK64,acK70 PRO 12408818
PR:000036566 (hSMAD7/iso:1/Phos:1) pS249 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9HAU4 (SMURF2) Y314 O15105 (SMAD7) inhibited_association eFIP 31554791


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O15105-1 (hSMAD7/iso:1) Interaction PRO 9256479


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T96 M96 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K101 T101 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T354 M354 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]