iPTMnet Report for O15083 (ERC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15083 / ERC2_HUMAN
Protein Name ERC protein 2
Gene Name Name: ERC2
Synonyms:KIAA0378;
Organism Homo sapiens (Human)

PRO ID PR:O15083
DAG View
PRO Name ERC protein 2 (human)
Definition An ERC protein 2 that is encoded in the genome of human.
Short Label hERC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15083 (ERC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T7 O-Glycosylation GlyGen 28657654
S14 Phosphorylation PhosphoSitePlus
S18 Phosphorylation HPRD   PhosphoSitePlus 20068231
S24 Phosphorylation PhosphoSitePlus
T32 Phosphorylation HPRD   PhosphoSitePlus 18452278
S34 Phosphorylation HPRD   PhosphoSitePlus 18452278
S65 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S187 Phosphorylation HPRD   PhosphoSitePlus 18767875, 17924679
R194 Methylation PhosphoSitePlus
R197 Methylation PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
R203 Methylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S314 Phosphorylation HPRD   PhosphoSitePlus 20068231
S319 Phosphorylation HPRD   PhosphoSitePlus 20068231
S321 Phosphorylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
K879 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S18 F18 Biomuta DOID:4159 / skin cancer [ cosmic ]
S187 N187 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R194 K194 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R197 K197 Biomuta DOID:4159 / skin cancer [ cosmic ]
R203 W203 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R203 Q203 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
S321 R321 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S321 N321 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S321 I321 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]