Protein Information

Cytoscape View


UniProt AC / UniProt ID O15078 / CE290_HUMAN
Protein Name Centrosomal protein of 290 kDa
Gene Name Name: CEP290
Synonyms:BBS14,KIAA0373,NPHP6;
Organism Homo sapiens (Human)

PRO ID PR:O15078
DAG View
PRO Name centrosomal protein of 290 kDa (human)
Definition A centrosomal protein of 290 kDa that is encoded in the genome of human.
Short Label hCEP290
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15078 (CEP290) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K140 Acetylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
T382 Phosphorylation PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
T569 Phosphorylation PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
T832 Phosphorylation PhosphoSitePlus
K846 Acetylation PhosphoSitePlus
K859 Acetylation PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus
T902 Phosphorylation PhosphoSitePlus
K951 Ubiquitination PhosphoSitePlus
K1033 Ubiquitination PhosphoSitePlus
K1045 Ubiquitination PhosphoSitePlus
S1046 Phosphorylation PhosphoSitePlus
T1060 Phosphorylation PhosphoSitePlus
S1159 Phosphorylation PhosphoSitePlus
K1178 Ubiquitination PhosphoSitePlus
S1209 Phosphorylation PhosphoSitePlus
K1336 Ubiquitination PhosphoSitePlus
K1360 Ubiquitination PhosphoSitePlus
K1517 Ubiquitination PhosphoSitePlus
K1552 Ubiquitination PhosphoSitePlus
K1598 Ubiquitination PhosphoSitePlus
K1600 Ubiquitination PhosphoSitePlus
K1608 Ubiquitination PhosphoSitePlus
S1610 Phosphorylation PhosphoSitePlus
K1618 Ubiquitination PhosphoSitePlus
K1684 Acetylation PhosphoSitePlus
K1691 Acetylation PhosphoSitePlus
S1697 Phosphorylation phospho.ELM 17081983
K1731 Acetylation PhosphoSitePlus
K1737 Acetylation PhosphoSitePlus
K1788 Ubiquitination PhosphoSitePlus
K1828 Acetylation PhosphoSitePlus
K1840 Acetylation PhosphoSitePlus
K1864 Ubiquitination PhosphoSitePlus
K1906 Ubiquitination PhosphoSitePlus
K1916 Methylation PhosphoSitePlus
K1921 Methylation PhosphoSitePlus
T1959 Phosphorylation PhosphoSitePlus
T1966 Phosphorylation PhosphoSitePlus
Y2002 Phosphorylation PhosphoSitePlus
S2013 Phosphorylation PhosphoSitePlus
K2034 Ubiquitination PhosphoSitePlus
K2043 Ubiquitination PhosphoSitePlus
S2045 Phosphorylation PhosphoSitePlus
T2126 Phosphorylation PhosphoSitePlus
S2155 Phosphorylation PhosphoSitePlus
K2172 Ubiquitination PhosphoSitePlus
S2189 Phosphorylation PhosphoSitePlus
T2284 Phosphorylation PhosphoSitePlus
T2294 Phosphorylation PhosphoSitePlus
T2304 Phosphorylation PhosphoSitePlus
K2322 Ubiquitination PhosphoSitePlus
K2338 Ubiquitination PhosphoSitePlus
S2369 Phosphorylation PhosphoSitePlus
S2395 Phosphorylation PhosphoSitePlus
K2437 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T580 Phosphorylation HPRD 20068231
S895 Phosphorylation HPRD 19664995
S1697 Phosphorylation HPRD 17081983
S2069 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K191 I191 Biomuta DOID:263 / kidney cancer [ cosmic ]
T382 N382 Biomuta DOID:3571 / liver cancer [ icgc ]
Y451 * Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K512 N512 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:4362 / cervical cancer [ tcga ]
K527 Q527 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K527 * Biomuta DOID:1319 / brain cancer [ icgc ]
K1045 Q1045 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K1045 T1045 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K1517 N1517 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1906 N1906 Biomuta DOID:363 / uterine cancer [ tcga ]
K1916 T1916 Biomuta DOID:363 / uterine cancer [ tcga ]
K1921 E1921 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2069 L2069 Biomuta DOID:1115 / sarcoma [ tcga ]
S2189 I2189 Biomuta DOID:1324 / lung cancer [ tcga ]