iPTMnet Report for O15075 (DCLK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15075 / DCLK1_HUMAN
Protein Name Serine/threonine-protein kinase DCLK1
Gene Name Name: DCLK1
Synonyms:DCAMKL1,DCDC3A,KIAA0369;
Organism Homo sapiens (Human)

PRO ID PR:O15075
DAG View
PRO Name serine/threonine-protein kinase DCLK1 (human)
Definition A serine/threonine-protein kinase DCLK1 that is encoded in the genome of human.
Short Label hDCLK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15075 (DCLK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus   UniProt 21406692
S353 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
Y493 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus
S729 Phosphorylation PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S330 Phosphorylation HPRD 19413330, 19651622, 19664994
S332 Phosphorylation HPRD 19413330, 19651622
S334 Phosphorylation HPRD 19413330
T336 Phosphorylation HPRD 19413330, 19664995
S337 Phosphorylation HPRD 19413330, 19651622, 19664995
S352 Phosphorylation HPRD 15345747
S722 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 R32 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T34 K34 Biomuta DOID:4159 / skin cancer [ cosmic ]
T34 M34 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S36 R36 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T46 M46 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
Y74 H74 Biomuta DOID:363 / uterine cancer [ icgc ]
Y74 N74 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S77 F77 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic, icgc, cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S274 T274 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S305 G305 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S307 F307 Biomuta DOID:3571 / liver cancer [ cosmic ]
S330 L330 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S334 L334 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S337 I337 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S337 N337 Biomuta DOID:363 / uterine cancer [ icgc ]
S353 F353 Biomuta DOID:4159 / skin cancer [ cosmic ]
S720 L720 Biomuta DOID:4159 / skin cancer [ cosmic ]
S729 C729 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S738 L738 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]