iPTMnet Report for O15067 (PFAS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15067 / PUR4_HUMAN
Protein Name Phosphoribosylformylglycinamidine synthase
Gene Name Name: PFAS
Synonyms:KIAA0361;
Organism Homo sapiens (Human)

PRO ID PR:O15067
DAG View
PRO Name phosphoribosylformylglycinamidine synthase (human)
Definition A phosphoribosylformylglycinamidine synthase that is encoded in the genome of human.
Short Label hPFAS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15067 (PFAS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K59 Ubiquitination PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
C108 Methylation IEDB 31844290
R118 Methylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus   UniProt 23186163
T216 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
R231 Methylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
R282 Methylation PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
R302 Methylation PhosphoSitePlus
S321 O-Glycosylation GlyGen 23301498, 35138101, 34725712, ...30059200, 32870666, 32119511, 28510447
K395 Sumoylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
Y457 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
Y538 Phosphorylation PhosphoSitePlus
T539 Phosphorylation PhosphoSitePlus
S569 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19651622, 20068231
T576 Phosphorylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
T619 Phosphorylation PhosphoSitePlus   Signor   UniProt 19690332, 20068231, 32485148
T619 Phosphorylation P28482 (MAPK1) Signor 32485148
T623 Phosphorylation PhosphoSitePlus   UniProt 19690332
K639 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
T681 Phosphorylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus
S873 Phosphorylation PhosphoSitePlus
S893 Phosphorylation PhosphoSitePlus
K900 Ubiquitination PhosphoSitePlus
R1033 Methylation PhosphoSitePlus
K1051 Ubiquitination PhosphoSitePlus
S1062 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1119 Phosphorylation PhosphoSitePlus
S1337 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R118 C118 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
R231 L231 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R231 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K507 N507 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T539 P539 Biomuta [ cosmic ]
K900 T900 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]