iPTMnet Report for O15055 (PER2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15055 / PER2_HUMAN
Protein Name Period circadian protein homolog 2
Gene Name Name: PER2
Synonyms:KIAA0347;
Organism Homo sapiens (Human)

PRO ID PR:O15055
DAG View
PRO Name period circadian protein homolog 2 (human)
Definition A period circadian protein homolog 2 that is encoded in the genome of human.
Short Label hPER2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15055 (PER2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Ubiquitination PRO
S53 Phosphorylation RLIMS-P 19491384
S77 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
C166 Methylation IEDB 31844290
S259 Phosphorylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
C449 Methylation IEDB 31844290
K453 Ubiquitination PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
K539 Acetylation PhosphoSitePlus
K553 Acetylation PhosphoSitePlus
S566 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 23395175
S580 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 23395175
S627 Phosphorylation PhosphoSitePlus
T645 Phosphorylation PhosphoSitePlus
T649 Phosphorylation PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
S653 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 23395175
S662 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 23395175
S662 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11232563, 17218255, 21324900, ...11475410
S662 Phosphorylation P48730 (CSNK1D) PhosphoSitePlus 21324900
S662 Phosphorylation P49674 (CSNK1E) PhosphoSitePlus 11232563, 21324900
S665 Phosphorylation PhosphoSitePlus 21324900
S665 Phosphorylation P48730 (CSNK1D) PhosphoSitePlus 21324900
S665 Phosphorylation P49674 (CSNK1E) PhosphoSitePlus 21324900
S668 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 23395175
S668 Phosphorylation PhosphoSitePlus 21324900
S668 Phosphorylation P48730 (CSNK1D) PhosphoSitePlus 21324900
S668 Phosphorylation P49674 (CSNK1E) PhosphoSitePlus 21324900
S671 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 23395175
S696 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus
T734 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 23395175
K744 Ubiquitination PhosphoSitePlus
C758 Methylation IEDB 31844290
S766 Phosphorylation PhosphoSitePlus
T774 Phosphorylation PhosphoSitePlus
T781 Phosphorylation PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus
S786 Phosphorylation PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
T965 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 23395175
T968 Phosphorylation PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
S983 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 23395175
S1105 Phosphorylation PhosphoSitePlus
S1108 Phosphorylation PhosphoSitePlus
S1109 Phosphorylation PhosphoSitePlus
T1180 O-Glycosylation GlyGen 30379171, 23395175
K1184 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S662 Phosphorylation HPRD 11232563, 9349507
S662 Phosphorylation P49674 (CSNK1E) HPRD 11232563, 9349507
S665 Phosphorylation HPRD 17218255
S665 Phosphorylation P49674 (CSNK1E) HPRD 17218255
S668 Phosphorylation HPRD 17218255
S668 Phosphorylation P49674 (CSNK1E) HPRD 17218255
S671 Phosphorylation HPRD 17218255
S671 Phosphorylation P49674 (CSNK1E) HPRD 17218255
S674 Phosphorylation HPRD 17218255
S674 Phosphorylation P49674 (CSNK1E) HPRD 17218255
S977 Phosphorylation HPRD 16097765
S977 Phosphorylation P48730 (CSNK1D) HPRD 16097765


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048747 (hPER2/PhosSer+) p PRO
PR:000048748 (hPER2/pSerUbiq+) p PRO
PR:000048748 (hPER2/pSerUbiq+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S53 L53 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K113 T113 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S259 Y259 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K384 N384 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K553 R553 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S566 G566 Biomuta DOID:263 / kidney cancer [ cosmic ]
T645 M645 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T649 R649 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S653 L653 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S665 P665 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S665 L665 Biomuta DOID:1324 / lung cancer [ cosmic ]
S700 F700 Biomuta DOID:4159 / skin cancer [ cosmic ]
T968 P968 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1108 F1108 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1180 M1180 Biomuta DOID:9256 / colorectal cancer [ cosmic ]