iPTMnet Report for O15047 (SETD1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15047 / SET1A_HUMAN
Protein Name Histone-lysine N-methyltransferase SETD1A
Gene Name Name: SETD1A
Synonyms:KIAA0339;
Organism Homo sapiens (Human)

PRO ID PR:O15047
DAG View
PRO Name histone-lysine N-methyltransferase SETD1A (human)
Definition A histone-lysine N-methyltransferase SETD1A that is encoded in the genome of human.
Short Label hSETD1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15047 (SETD1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K21 Ubiquitination PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
Y179 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
T256 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...30379171, 32574038, 34019948, 21740066, 35254053, 35132862, 30620550, 31492838, 20305658, 32119511, 35289036, 29351928, 30059200
S268 Phosphorylation PhosphoSitePlus
T271 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...30379171, 32574038, 34019948, 21740066, 35254053, 35132862, 30620550, 31492838, 20305658, 32119511, 35289036, 29351928, 30059200
T271 Phosphorylation PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
T274 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...30379171, 32574038, 34019948, 21740066, 35254053, 35132862, 30620550, 31492838, 20305658, 32119511, 35289036, 29351928, 30059200
T274 Phosphorylation PhosphoSitePlus
S275 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...30379171, 32574038, 34019948, 21740066, 35254053, 35132862, 30620550, 31492838, 20305658, 32119511, 35289036, 29351928, 30059200
R276 Methylation PhosphoSitePlus
S278 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...30397120, 30379171, 32574038, 34019948, 21740066, 35254053, 35132862, 30620550, 31492838, 20305658, 32119511, 35289036, 29351928, 30059200
T279 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...30379171, 32574038, 34019948, 21740066, 35254053, 35132862, 30620550, 31492838, 20305658, 32119511, 35289036, 29351928, 30059200
S282 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...30379171, 32574038, 34019948, 21740066, 35254053, 35132862, 30620550, 31492838, 20305658, 32119511, 35289036, 29351928, 30059200
S282 Phosphorylation PhosphoSitePlus
S288 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...30379171, 32574038, 34019948, 21740066, 35254053, 35132862, 30620550, 31492838, 20305658, 32119511, 35289036, 29351928, 30059200
S290 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...30379171, 32574038, 34019948, 21740066, 35254053, 35132862, 30620550, 31492838, 20305658, 32119511, 35289036, 29351928, 30059200
T291 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...30379171, 32574038, 34019948, 21740066, 35254053, 35132862, 30620550, 31492838, 20305658, 32119511, 35289036, 29351928, 30059200
S293 Phosphorylation PhosphoSitePlus
S301 O-Glycosylation GlyGen 30620550
S315 Phosphorylation PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
Y370 Phosphorylation PhosphoSitePlus
T388 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus   UniProt 23186163
S464 Phosphorylation PhosphoSitePlus   UniProt 23186163
S468 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231, 20230923
S470 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278, 20230923
T476 Phosphorylation HPRD   phospho.ELM 18669648
S501 Phosphorylation PhosphoSitePlus
S504 Phosphorylation HPRD   PhosphoSitePlus 18452278
S508 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19690332, 18452278
T510 Phosphorylation HPRD   PhosphoSitePlus 18452278
S534 Phosphorylation PhosphoSitePlus
T540 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935, 18452278
T562 Phosphorylation PhosphoSitePlus
S565 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18452278
S586 Phosphorylation PhosphoSitePlus
K803 Acetylation PhosphoSitePlus
S882 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
K898 Acetylation PhosphoSitePlus
S904 Phosphorylation HPRD 20068231
S907 Phosphorylation HPRD   PhosphoSitePlus 20068231
K910 Acetylation PhosphoSitePlus
S915 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983
T916 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17081983
K950 Acetylation PhosphoSitePlus
K954 Acetylation PhosphoSitePlus
S958 Phosphorylation HPRD 18452278
S963 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18452278
S969 Phosphorylation HPRD   PhosphoSitePlus 19651622
S972 Phosphorylation HPRD 19651622
S973 Phosphorylation HPRD 19651622
S1004 Phosphorylation PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus
S1038 Phosphorylation PhosphoSitePlus
S1039 Phosphorylation PhosphoSitePlus
S1040 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation PhosphoSitePlus
S1046 Phosphorylation PhosphoSitePlus
S1047 Phosphorylation PhosphoSitePlus
S1048 Phosphorylation PhosphoSitePlus
S1049 Phosphorylation PhosphoSitePlus
T1088 Phosphorylation PhosphoSitePlus
S1103 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664994, 24275569, 18452278
T1106 Phosphorylation PhosphoSitePlus
S1114 Phosphorylation PhosphoSitePlus
T1167 Phosphorylation PhosphoSitePlus
S1169 Phosphorylation PhosphoSitePlus
S1171 Phosphorylation PhosphoSitePlus
T1185 Phosphorylation PhosphoSitePlus
T1206 Phosphorylation PhosphoSitePlus
S1216 Phosphorylation HPRD   PhosphoSitePlus 20068231
R1227 Methylation PhosphoSitePlus
S1545 Phosphorylation PhosphoSitePlus
T1549 Phosphorylation PhosphoSitePlus
S1550 Phosphorylation PhosphoSitePlus
K1637 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y179 H179 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S222 F222 Biomuta DOID:4159 / skin cancer [ cosmic ]
T274 K274 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T274 M274 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R276 Q276 Biomuta DOID:363 / uterine cancer [ icgc ]
R276 W276 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S349 L349 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S352 F352 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S352 C352 Biomuta DOID:3571 / liver cancer [ cosmic ]
S352 P352 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y370 F370 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y370 C370 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S459 F459 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S464 F464 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S470 F470 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S501 F501 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S504 F504 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K803 N803 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S904 F904 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
K910 E910 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S973 F973 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1040 T1040 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1048 L1048 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1169 F1169 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1169 A1169 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1185 I1185 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T1206 I1206 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1216 F1216 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T1549 P1549 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1637 T1637 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]