iPTMnet Report for O15042 (U2SURP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15042 / SR140_HUMAN
Protein Name U2 snRNP-associated SURP motif-containing protein
Gene Name Name: U2SURP
Synonyms:KIAA0332,SR140;
Organism Homo sapiens (Human)

PRO ID PR:O15042
DAG View
PRO Name U2 snRNP-associated SURP motif-containing protein (human)
Definition A U2 snRNP-associated SURP motif-containing protein that is encoded in the genome of human.
Short Label hU2SURP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15042 (U2SURP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K4 Acetylation PhosphoSitePlus
T5 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
C65 Methylation IEDB 31844290
S67 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...32522876, 34019948, 35132862, 28510447
S67 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S73 Phosphorylation PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K82 Methylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K88 Methylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
R137 Methylation PhosphoSitePlus
K145 Sumoylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K156 Acetylation PhosphoSitePlus
Y158 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S181 Phosphorylation IEDB   PhosphoSitePlus 32387766
S202 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K208 Sumoylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus   UniProt 23186163
S238 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
C291 Methylation IEDB 31844290
K392 Ubiquitination PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S485 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 15302935, ...20068231
T487 Phosphorylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
R547 Methylation PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
Y634 Phosphorylation PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
T719 Phosphorylation PhosphoSitePlus   UniProt 24275569
K730 Sumoylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
K760 Acetylation PhosphoSitePlus   UniProt 19608861
K760 Sumoylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692, 19690332
S800 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332
S811 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
Y817 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
K822 Sumoylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
K832 Methylation PhosphoSitePlus
K832 Sumoylation PhosphoSitePlus
Y833 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
K902 Acetylation PhosphoSitePlus
K904 Acetylation PhosphoSitePlus
K910 Acetylation PhosphoSitePlus
K912 Acetylation PhosphoSitePlus
T919 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T921 Phosphorylation PhosphoSitePlus
S930 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T931 Phosphorylation PhosphoSitePlus   UniProt 20068231
S932 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S934 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S936 Phosphorylation PhosphoSitePlus
S938 Phosphorylation PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
S940 Phosphorylation PhosphoSitePlus
S946 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 15302935, 20068231, 27869121, ...17081983
S948 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 17081983, 20068231
S951 Phosphorylation PhosphoSitePlus
S957 Phosphorylation PhosphoSitePlus
S969 Phosphorylation PhosphoSitePlus
S970 Phosphorylation PhosphoSitePlus
S974 Phosphorylation PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
S985 Phosphorylation PhosphoSitePlus
S987 Phosphorylation PhosphoSitePlus
S989 Phosphorylation PhosphoSitePlus
T991 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
S1014 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S63 Phosphorylation HPRD 20068231
S67 Phosphorylation HPRD 20068231
S73 Phosphorylation HPRD 20068231
T95 Phosphorylation HPRD 20068231
S97 Phosphorylation HPRD 20068231
S265 Phosphorylation HPRD 20068231
S479 Phosphorylation HPRD 20068231
S485 Phosphorylation HPRD 19413330, 18767875, 19664994, ...19664995, 19651622, 18669648, 19415658, 20068231
T487 Phosphorylation HPRD 19651622, 18767875, 18669648
S731 Phosphorylation HPRD 19651622
S788 Phosphorylation HPRD 18669648, 18452278
S800 Phosphorylation HPRD 18669648, 18452278
S811 Phosphorylation HPRD 19651622, 18767875, 20068231, ...18452278
Y817 Phosphorylation HPRD 18452278
T921 Phosphorylation HPRD 20068231
S930 Phosphorylation HPRD 19651622, 20068231
T931 Phosphorylation HPRD 19651622, 20068231
S932 Phosphorylation HPRD 19651622, 20068231
S934 Phosphorylation HPRD 19651622, 20068231
S936 Phosphorylation HPRD 19651622, 20068231
S946 Phosphorylation HPRD 20068231
S948 Phosphorylation HPRD 20068231
S1010 Phosphorylation HPRD 19651622
S1012 Phosphorylation HPRD 19651622
S1014 Phosphorylation HPRD 19651622
S1016 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K4 E4 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T5 S5 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S26 P26 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S34 Y34 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S37 L37 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S49 G49 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S49 I49 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S59 R59 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S63 N63 Biomuta DOID:1319 / brain cancer [ cosmic ]
S67 F67 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S85 N85 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S85 I85 Biomuta DOID:1319 / brain cancer [ cosmic ]
T91 A91 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S97 R97 Biomuta DOID:263 / kidney cancer [ cosmic ]
K133 E133 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K145 E145 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y158 C158 Biomuta DOID:3571 / liver cancer [ cosmic ]
K159 T159 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S244 P244 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
C291 F291 Biomuta DOID:1324 / lung cancer [ cosmic ]
S485 Y485 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S818 T818 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S934 C934 Biomuta DOID:1324 / lung cancer [ cosmic ]
S946 F946 Biomuta DOID:4159 / skin cancer [ cosmic ]
S951 L951 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1014 F1014 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1016 T1016 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
S1016 F1016 Biomuta DOID:4159 / skin cancer [ cosmic ]