iPTMnet Report for O15021 (MAST4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15021 / MAST4_HUMAN
Protein Name Microtubule-associated serine/threonine-protein kinase 4
Gene Name Name: MAST4
Synonyms:KIAA0303;
Organism Homo sapiens (Human)

PRO ID PR:O15021
DAG View
PRO Name microtubule-associated serine/threonine-protein kinase 4 (human)
Definition A microtubule-associated serine/threonine-protein kinase 4 that is encoded in the genome of human.
Short Label hMAST4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15021 (MAST4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
R164 Methylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus   UniProt 23186163
S285 Phosphorylation PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
T723 Phosphorylation PhosphoSitePlus
T724 Phosphorylation PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
R828 Methylation PhosphoSitePlus
K838 Ubiquitination PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
S864 Phosphorylation PhosphoSitePlus
Y870 Phosphorylation PhosphoSitePlus
T883 Phosphorylation PhosphoSitePlus
S902 Phosphorylation PhosphoSitePlus
S903 Phosphorylation PhosphoSitePlus
S914 Phosphorylation PhosphoSitePlus   UniProt 23186163
T943 Phosphorylation PhosphoSitePlus
S945 Phosphorylation PhosphoSitePlus
S959 Phosphorylation PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
T964 Phosphorylation PhosphoSitePlus
S966 Phosphorylation PhosphoSitePlus
S973 Phosphorylation PhosphoSitePlus
T1235 Phosphorylation PhosphoSitePlus
S1242 Phosphorylation PhosphoSitePlus
S1275 Phosphorylation PhosphoSitePlus
S1283 Phosphorylation PhosphoSitePlus
S1290 Phosphorylation PhosphoSitePlus
S1292 Phosphorylation PhosphoSitePlus
S1296 Phosphorylation PhosphoSitePlus
S1300 Phosphorylation PhosphoSitePlus
S1309 Phosphorylation PhosphoSitePlus
S1370 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S1377 Phosphorylation PhosphoSitePlus
T1382 Phosphorylation PhosphoSitePlus
S1384 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1386 Phosphorylation PhosphoSitePlus
T1390 Phosphorylation PhosphoSitePlus
S1391 Phosphorylation PhosphoSitePlus
S1397 Phosphorylation PhosphoSitePlus
S1415 Phosphorylation PhosphoSitePlus
S1419 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1422 Phosphorylation PhosphoSitePlus
S1432 Phosphorylation PhosphoSitePlus
S1438 Phosphorylation PhosphoSitePlus
K1442 Methylation PhosphoSitePlus
S1446 Phosphorylation PhosphoSitePlus
S1467 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1523 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1586 Phosphorylation PhosphoSitePlus
S1592 Phosphorylation PhosphoSitePlus
R1637 Methylation PhosphoSitePlus
R1638 Methylation PhosphoSitePlus
S1652 Phosphorylation PhosphoSitePlus
S1694 Phosphorylation PhosphoSitePlus
T1769 Phosphorylation PhosphoSitePlus
S1779 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S1786 Phosphorylation PhosphoSitePlus
S1822 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1838 Phosphorylation PhosphoSitePlus
S1845 Phosphorylation PhosphoSitePlus
S1846 Phosphorylation PhosphoSitePlus
S1847 Phosphorylation PhosphoSitePlus
S1855 Phosphorylation PhosphoSitePlus
S1860 Phosphorylation PhosphoSitePlus
K1865 Methylation PhosphoSitePlus
K1868 Methylation PhosphoSitePlus
T1906 Phosphorylation PhosphoSitePlus
S1909 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1912 Phosphorylation PhosphoSitePlus
S1916 Phosphorylation PhosphoSitePlus
S1947 Phosphorylation PhosphoSitePlus
S1997 Phosphorylation PhosphoSitePlus
S2091 Phosphorylation PhosphoSitePlus
S2131 Phosphorylation PhosphoSitePlus
S2132 Phosphorylation PhosphoSitePlus
S2213 Phosphorylation PhosphoSitePlus
S2231 Phosphorylation PhosphoSitePlus
S2235 Phosphorylation PhosphoSitePlus
S2243 Phosphorylation PhosphoSitePlus
S2245 Phosphorylation PhosphoSitePlus
T2277 Phosphorylation IEDB 35494241
S2330 Phosphorylation PhosphoSitePlus
Y2379 Phosphorylation PhosphoSitePlus
S2392 Phosphorylation PhosphoSitePlus
S2396 Phosphorylation PhosphoSitePlus
S2440 Phosphorylation PhosphoSitePlus
S2442 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2460 Phosphorylation PhosphoSitePlus
S2520 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S2552 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2613 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation PhosphoSitePlus
S784 Phosphorylation HPRD 20068231
T1717 Phosphorylation HPRD 20068231
T1723 Phosphorylation HPRD 17924679
S1727 Phosphorylation HPRD 17924679
S2331 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
S114 Phosphorylation HPRD 17525332
S224 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S137 G137 Biomuta DOID:3571 / liver cancer [ cosmic ]
R164 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S206 L206 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S213 N213 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S248 L248 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S268 T268 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S285 W285 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
S353 F353 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S784 A784 Biomuta DOID:3571 / liver cancer [ cosmic ]
T943 I943 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S973 A973 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1290 T1290 Biomuta DOID:10534 / stomach cancer [ tcga ]
S1370 F1370 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1382 A1382 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1397 F1397 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1419 F1419 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1446 F1446 Biomuta DOID:4159 / skin cancer [ icgc ]
S1467 N1467 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R1638 Q1638 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1717 I1717 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1769 M1769 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1779 Y1779 Biomuta DOID:1324 / lung cancer [ icgc ]
T1906 I1906 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2213 A2213 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2213 F2213 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2440 T2440 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S2442 A2442 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S2460 I2460 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S2552 L2552 Biomuta DOID:1324 / lung cancer [ cosmic ]