iPTMnet Report for O15013 (ARHGEF10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15013 / ARHGA_HUMAN
Protein Name Rho guanine nucleotide exchange factor 10
Gene Name Name: ARHGEF10
Synonyms:KIAA0294;
Organism Homo sapiens (Human)

PRO ID PR:O15013
DAG View
PRO Name Rho guanine nucleotide exchange factor 10 (human)
Definition A Rho guanine nucleotide exchange factor 10 that is encoded in the genome of human.
Short Label hARHGEF10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15013 (ARHGEF10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S59 Phosphorylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
T409 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
K441 Sumoylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
Y629 Phosphorylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
Y640 Phosphorylation PhosphoSitePlus
T677 Phosphorylation phospho.ELM 18669648
Y710 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
T980 Phosphorylation PhosphoSitePlus
Y1036 Phosphorylation PhosphoSitePlus
S1229 Phosphorylation PhosphoSitePlus
S1232 Phosphorylation PhosphoSitePlus
S1283 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1284 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1285 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1287 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1289 Phosphorylation PhosphoSitePlus
S1291 Phosphorylation PhosphoSitePlus
S1294 Phosphorylation PhosphoSitePlus
S1296 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1301 Phosphorylation PhosphoSitePlus
Y1307 Phosphorylation PhosphoSitePlus
K1311 Ubiquitination PhosphoSitePlus
S1315 Phosphorylation PhosphoSitePlus
Q1338 Methylation UniProt 26797129
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 19664995
S354 Phosphorylation HPRD 19651622, 20068231
T652 Phosphorylation HPRD 18669648
S1257 Phosphorylation HPRD 17081983
S1258 Phosphorylation HPRD 18669648
S1259 Phosphorylation HPRD 19651622, 18669648
S1260 Phosphorylation HPRD 19651622, 18669648, 17081983
S1262 Phosphorylation HPRD 18669648, 17081983
S1271 Phosphorylation HPRD 18669648
Y1282 Phosphorylation HPRD 18707149


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y239 D239 Biomuta DOID:4159 / skin cancer [ cosmic ]
S308 Y308 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K378 M378 Biomuta DOID:11934 / head and neck cancer [ icgc ]
K441 N441 Biomuta DOID:4159 / skin cancer [ cosmic ]
T980 I980 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1229 T1229 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1257 Y1257 Biomuta DOID:10534 / stomach cancer [ icgc ]
S1315 L1315 Biomuta DOID:2531 / hematologic cancer [ cosmic ]