Protein Information

Cytoscape View


UniProt AC / UniProt ID O14983 / AT2A1_HUMAN
Protein Name Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Gene Name Name: ATP2A1
Organism Homo sapiens (Human)

PRO ID PR:O14983
DAG View
PRO Name sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (human)
Definition A sarcoplasmic/endoplasmic reticulum calcium ATPase 1 that is encoded in the genome of human.
Short Label hATP2A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14983 (ATP2A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K218 Acetylation PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
Y294 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
C344 S-Nitrosylation dbSNO 10493809
T345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
C349 S-Nitrosylation dbSNO 10493809
S473 Phosphorylation PhosphoSitePlus
K481 Acetylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
K492 Acetylation PhosphoSitePlus
Y497 Phosphorylation PhosphoSitePlus
K515 Acetylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
Y527 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
T608 Phosphorylation PhosphoSitePlus
T625 Phosphorylation PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus
T724 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
T742 Phosphorylation PhosphoSitePlus
K758 Acetylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
S830 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T446 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T446 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K328 N328 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S335 R335 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S346 C346 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S473 P473 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S473 L473 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T608 M608 Biomuta DOID:363 / uterine cancer [ tcga ]
T625 I625 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K684 N684 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K684 T684 Biomuta DOID:363 / uterine cancer [ tcga ]