iPTMnet Report for O14983 (ATP2A1)
Protein Information
UniProt AC / UniProt ID | O14983 / AT2A1_HUMAN |
Protein Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
Gene Name | Name: ATP2A1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:O14983 |
PRO Name | sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (human) |
Definition | A sarcoplasmic/endoplasmic reticulum calcium ATPase 1 that is encoded in the genome of human. |
Short Label | hATP2A1 |
Category | organism-gene |
O14983 (ATP2A1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
K120 | Ubiquitination | score1 | PhosphoSitePlus | |||
K128 | Ubiquitination | score1 | PhosphoSitePlus | |||
S170 | Phosphorylation | score1 | PhosphoSitePlus | |||
S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
S186 | Phosphorylation | score1 | PhosphoSitePlus | |||
K205 | Ubiquitination | score1 | PhosphoSitePlus | |||
K218 | Acetylation | score1 | PhosphoSitePlus | |||
T226 | Phosphorylation | score1 | IEDB | 27869121 | ||
T230 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 27869121 | ||
K252 | Ubiquitination | score1 | PhosphoSitePlus | |||
S261 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y294 | Phosphorylation | score1 | PhosphoSitePlus | |||
K328 | Ubiquitination | score1 | PhosphoSitePlus | |||
K329 | Ubiquitination | score1 | PhosphoSitePlus | |||
S335 | Phosphorylation | score1 | PhosphoSitePlus | |||
S338 | Phosphorylation | score1 | PhosphoSitePlus | |||
C344 | S-Nitrosylation | score1 | dbSNO | 10493809 | ||
T345 | Phosphorylation | score1 | PhosphoSitePlus | |||
S346 | Phosphorylation | score1 | PhosphoSitePlus | |||
C349 | S-Nitrosylation | score1 | dbSNO | 10493809 | ||
S473 | Phosphorylation | score1 | PhosphoSitePlus | |||
K481 | Acetylation | score1 | PhosphoSitePlus | |||
K481 | Ubiquitination | score1 | PhosphoSitePlus | |||
T484 | Phosphorylation | score1 | PhosphoSitePlus | |||
S488 | Phosphorylation | score1 | PhosphoSitePlus | |||
K492 | Acetylation | score1 | PhosphoSitePlus | |||
Y497 | Phosphorylation | score1 | PhosphoSitePlus | |||
K515 | Acetylation | score1 | PhosphoSitePlus | |||
K515 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y527 | Phosphorylation | score1 | PhosphoSitePlus | |||
S581 | Phosphorylation | score1 | PhosphoSitePlus | |||
T608 | Phosphorylation | score1 | PhosphoSitePlus | |||
T625 | Phosphorylation | score1 | PhosphoSitePlus | |||
K684 | Ubiquitination | score1 | PhosphoSitePlus | |||
K713 | Ubiquitination | score1 | PhosphoSitePlus | |||
S722 | Phosphorylation | score1 | PhosphoSitePlus | |||
T724 | Phosphorylation | score1 | PhosphoSitePlus | |||
S731 | Phosphorylation | score1 | PhosphoSitePlus | |||
S741 | Phosphorylation | score1 | PhosphoSitePlus | |||
T742 | Phosphorylation | score1 | PhosphoSitePlus | |||
K758 | Acetylation | score1 | PhosphoSitePlus | |||
K758 | Ubiquitination | score1 | PhosphoSitePlus | |||
S830 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K120 | N120 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S170 | F170 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] | |
S261 | F261 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S335 | R335 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S338 | F338 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S346 | C346 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S473 | P473 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S473 | L473 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
Y527 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T608 | M608 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K684 | T684 | Biomuta | DOID:363 / uterine cancer [ icgc ] |