iPTMnet Report for O14983 (ATP2A1)
Protein Information
| UniProt AC / UniProt ID | O14983 / AT2A1_HUMAN |
| Protein Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| Gene Name | Name: ATP2A1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O14983 |
| PRO Name | sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (human) |
| Definition | A sarcoplasmic/endoplasmic reticulum calcium ATPase 1 that is encoded in the genome of human. |
| Short Label | hATP2A1 |
| Category | organism-gene |
O14983 (ATP2A1) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K120 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K128 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S170 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S186 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K205 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K218 | Acetylation | score1 | PhosphoSitePlus | |||
| T226 | Phosphorylation | score1 | IEDB | 27869121 | ||
| T230 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 27869121 | ||
| K252 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S261 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K328 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K329 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S335 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S338 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C344 | S-Nitrosylation | score1 | dbSNO | 10493809 | ||
| T345 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S346 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C349 | S-Nitrosylation | score1 | dbSNO | 10493809 | ||
| S473 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K481 | Acetylation | score1 | PhosphoSitePlus | |||
| K481 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T484 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S488 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K492 | Acetylation | score1 | PhosphoSitePlus | |||
| Y497 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K515 | Acetylation | score1 | PhosphoSitePlus | |||
| K515 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y527 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S581 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T608 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T625 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K684 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K713 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S722 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T724 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S731 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S741 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T742 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K758 | Acetylation | score1 | PhosphoSitePlus | |||
| K758 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S830 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K120 | N120 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S170 | F170 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] | |
| S261 | F261 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S335 | R335 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S338 | F338 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S346 | C346 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S473 | P473 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S473 | L473 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| Y527 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T608 | M608 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K684 | T684 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
DAG View