Protein Information

Cytoscape View

UniProt AC / UniProt ID O14980 / XPO1_HUMAN
Protein Name Exportin-1
Gene Name Name: XPO1
Organism Homo sapiens (Human)

PRO ID PR:O14980
DAG View
PRO Name exportin-1 (human)
Definition An exportin-1 that is encoded in the genome of human.
Short Label hXPO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O14980 (XPO1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K22 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
T65 Phosphorylation HPRD   PhosphoSitePlus 20068231
K88 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K144 Acetylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
C164 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
T187 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
S387 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231
S389 Phosphorylation HPRD   PhosphoSitePlus 18691976
S391 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 17322306, ...18669648, 23729730, 20068231
S395 Phosphorylation HPRD   PhosphoSitePlus 17322306
S397 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
Y409 Phosphorylation PhosphoSitePlus
K415 Acetylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K446 Acetylation PhosphoSitePlus   UniProt 19608861
K446 Ubiquitination PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
K455 Acetylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
Y469 Phosphorylation PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
T519 Phosphorylation PhosphoSitePlus
C528 S-Nitrosylation dbSNO 19483679
K531 Acetylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K537 Acetylation PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
K568 Acetylation PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
K686 Acetylation PhosphoSitePlus
K686 Ubiquitination PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
K693 Acetylation PhosphoSitePlus   UniProt 19608861
K693 Ubiquitination PhosphoSitePlus
T694 Phosphorylation PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
K757 Acetylation PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
S764 Phosphorylation HPRD   PhosphoSitePlus 20068231
S802 Phosphorylation PhosphoSitePlus
T816 Phosphorylation PhosphoSitePlus
Y841 Phosphorylation PhosphoSitePlus
T1030 Phosphorylation HPRD 18691976
S1031 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 18669648, 23186163, ...18691976
R1043 Methylation PhosphoSitePlus
S1055 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 33017560, 15302935
C1070 S-Nitrosylation dbSNO 26338901

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14980 (XPO1) S391 P46060 (RANGAP1) increased_association eFIP 23729730
Phosphorylation O43474 (KLF4) S132 O14980 (XPO1) inhibited_association eFIP 29526737
Phosphorylation P46527 (CDKN1B) S10 O14980 (XPO1) unknown eFIP 11889117
Phosphorylation P46527 (CDKN1B) S10 O14980 (XPO1) unknown eFIP 25770303
Phosphorylation P46527 (CDKN1B) S10 O14980 (XPO1) unknown eFIP 27279267
Phosphorylation Q9NP71 (MLXIPL) S196 O14980 (XPO1) unknown eFIP 18606808

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025763 (hIRF3/iso:1/Phos:1) Interaction PR:O14980 (hXPO1) PRO 10805757
PR:000036638 (hNFATC1/iso:1/Phos:1) Interaction PR:O14980 (hXPO1) PRO 10866678
PR:O14980 (hXPO1) Interaction PR:000025763 (hIRF3/iso:1/Phos:1) PRO 10805757
PR:O95644-1 (hNFATC1/iso:C-alpha) increased Interaction PR:O14980 (hXPO1) PRO 10866678

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K54 N54 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K190 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y252 C252 Biomuta DOID:363 / uterine cancer [ tcga ]
Y252 N252 Biomuta DOID:1324 / lung cancer [ tcga ]
S387 C387 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S395 F395 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y409 H409 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y469 C469 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K531 I531 Biomuta DOID:2596 / larynx cancer [ cosmic ]
K680 Q680 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T1030 S1030 Biomuta DOID:1909 / melanoma [ cosmic ]
S1031 C1031 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R1043 P1043 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]