Protein Information

Cytoscape View


UniProt AC / UniProt ID O14976 / GAK_HUMAN
Protein Name Cyclin-G-associated kinase
Gene Name Name: GAK
Organism Homo sapiens (Human)

PRO ID PR:O14976
DAG View
PRO Name cyclin-G-associated kinase (human)
Definition A cyclin-G-associated kinase that is encoded in the genome of human.
Short Label hGAK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14976 (GAK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 19369195
S2 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S26 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T186 Phosphorylation PhosphoSitePlus
Y201 Phosphorylation PhosphoSitePlus
Y204 Phosphorylation PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
Y338 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus
Y371 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K395 Acetylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
Y403 Phosphorylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
Y412 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P+ 28135906
S421 Phosphorylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
R439 Methylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus   UniProt 18691976
S540 Phosphorylation PhosphoSitePlus
T583 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
Y615 Phosphorylation PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus
Y764 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus   UniProt 18691976
T776 Phosphorylation PhosphoSitePlus   UniProt 23186163
S778 Phosphorylation PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus   UniProt 24275569
S784 Phosphorylation phospho.ELM 18669648
S785 Phosphorylation PhosphoSitePlus
T794 Phosphorylation PhosphoSitePlus   UniProt 23186163
K801 Ubiquitination PhosphoSitePlus
T805 Phosphorylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
S812 Phosphorylation PhosphoSitePlus
S815 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S817 Phosphorylation PhosphoSitePlus
S826 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195, ...18669648, 19690332
S829 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...19369195, 18669648, 19690332
S834 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 19369195
S837 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
T908 Phosphorylation PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus   UniProt 19369195
S1096 Phosphorylation PhosphoSitePlus   UniProt 18691976
S1118 Phosphorylation PhosphoSitePlus
S1130 O-Glycosylation GlyGen 23301498, 29485866, 29351928
S1130 Phosphorylation PhosphoSitePlus
Y1149 Phosphorylation PhosphoSitePlus
S1151 Phosphorylation PhosphoSitePlus
S1154 Phosphorylation PhosphoSitePlus
S1168 Phosphorylation PhosphoSitePlus
K1172 Ubiquitination PhosphoSitePlus
S1176 Phosphorylation PhosphoSitePlus   UniProt 19369195
S1185 Phosphorylation PhosphoSitePlus   UniProt 19369195
R1192 Methylation PhosphoSitePlus
T1213 Phosphorylation PhosphoSitePlus
K1217 Ubiquitination PhosphoSitePlus
K1219 Ubiquitination PhosphoSitePlus
K1278 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 18691976
S456 Phosphorylation HPRD 18691976
Y615 Phosphorylation HPRD 19413330
S770 Phosphorylation HPRD 18691976
T776 Phosphorylation HPRD 18691976
S778 Phosphorylation HPRD 18691976
S780 Phosphorylation HPRD 18691976
S783 Phosphorylation HPRD 18691976
S784 Phosphorylation HPRD 18691976, 18669648
S785 Phosphorylation HPRD 18691976
S789 Phosphorylation HPRD 18691976
T805 Phosphorylation HPRD 18691976
S811 Phosphorylation HPRD 18691976
S812 Phosphorylation HPRD 18691976
S815 Phosphorylation HPRD 18691976, 18669648
S817 Phosphorylation HPRD 18691976
S826 Phosphorylation HPRD 18691976, 18669648, 18452278
S829 Phosphorylation HPRD 20166139, 18691976, 18669648, ...18452278
S834 Phosphorylation HPRD 18691976, 18669648
S837 Phosphorylation HPRD 18691976
S1096 Phosphorylation HPRD 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S73 C73 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y153 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y276 C276 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y285 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
Y412 H412 Biomuta DOID:363 / uterine cancer [ tcga ]
S421 T421 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S421 P421 Biomuta DOID:1319 / brain cancer [ icgc ]
S421 L421 Biomuta DOID:363 / uterine cancer [ tcga ]
K432 E432 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R439 W439 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
S589 N589 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S589 R589 Biomuta DOID:3571 / liver cancer [ icgc ]
K590 E590 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K617 E617 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S778 C778 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S784 R784 Biomuta DOID:3571 / liver cancer [ icgc ]
S811 F811 Biomuta DOID:1324 / lung cancer [ tcga ]
S812 F812 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S829 L829 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S1151 L1151 Biomuta DOID:1909 / melanoma [ tcga ] DOID:1324 / lung cancer [ tcga ]
K1172 N1172 Biomuta DOID:0070003 / blastoma [ cosmic ]
S1185 F1185 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11934 / head and neck cancer [ tcga ]